Best Selling Books by Melanie Gerth

Young children will enjoy learning simple subtraction as they watch ten touchable ladybirds disappear one by one, with the turn of each page.

Five raised ladybugs disappear one by one as they try to make their way home. On board pages.

Young ones will love learning to count backwards as they watch five touchable ladybugs disappear one by one.

Con este libro los niños pueden aprender a contar al revés de 10 a 1 las mariquitas plásticas que aparecen en las ventanas de las páginas. Una por una las mariquitas se van cuando entra otro animal.

From Little Scholastic comes this innovative and interactive book for toddlers of things on the go! Ages: 2-3. This fully interactive book of vehicles will keep little hands busy: pull-tabs, lift-the-flaps, touch-and-feels, and holographic foil makes learning about things that go fun for hours! Ages: 2-3. Introducing Little Schoalstic, a developmental publishing program of interactive boks created exclusively to give babies and toddlers a head start in learning. Every book features: * Interactive components * High color contrast * Rhyming, repetitive, or predictable text * Familiar subjects and surroundings * Simple concepts * Distinct leveling between the ages of 0-3 years

Illustrates a variety of transportation vehicles including trucks, cars, boats, trains, and planes.

Words are paired with shapes featuring texture, pop-ups, flaps to lift, and pull tabs.

Enhanced with pop-ups, pull-the-tabs, and bright illustrations, an oversized novelty book provides preschoolers with a fun-filled guide to the era of the dinosaurs.

A creative new way to learn colors and first words! Each book focuses on a favorite color, showing a variety of appealing images in the featured color. Children will learn to identify the color and the object as they pull tabs, lift flaps, and feel textures.

A creative new way to learn colors and first words Each book focuses on a favorite color, showing a variety of appealing images in the featured color. Children will learn to identify the color and the object as they pull tabs, lift flaps, and feel textures.

With "touch and feel" textures, holographic foil, sturdy cardboard flaps, and movable parts on every spread, these books offer children interactive fun and learning! With warm, woolly scarves to touch, brightly coloured ornaments to hang on a giant pop-up tree, and much more, this jumbo book is the perfect way to celebrate Christmas!

Simple text and pictures identify common objects which are green.

One by one, ten tactile bugs disappear. Young ones can feel their way through the sturdy, colorful pages of this innovative book, looking for the ladybugs while reinforcing the counting concept. (Baby/Preschool)

This interactive book teaches children about the parts of their bodies and how to do things like brush their teeth, tie a shoelace, and tell time.

Young readers will love learning to count in this illustrated adaptation of a well-known nursery rhyme. Watch as each of the five plush, touchable ducklings disappears one by one

A creative new way to learn colors and first words! Each book focuses on a favorite color, showing a variety of appealing images in the featured color. Children will learn to identify the color and the object as they pull tabs, lift flaps, and feel textures.

Young ones will love learning to count backwards from nine to one as touchable, squeaky rubber ducks race down a river.

Ion homeostasis is essential for proper neuronal function, since changes in intra- or extracellular ion concentrations can cause neuropathological conditions including seizures and neuropathic pain. The Clˉ gradient determines the strength and polarity of GABAergic neurotransmission. It is established by the activity of cation-chloride cotransporters (CCCs), the K+-Clˉ co-transporter 2 (KCC2) and the Na+-K+-2Clˉ co- transporter 1 (NKCC1). To investigate how changes in Clˉ concentration in inhibitory neurons affect GABAergic neurotransmission and overall excitability, KCC2 expression was inhibited in parvalbuminergic (PV+) interneurons of C57BL/6 mice. KO mice showed an ataxic gait, spontaneous epileptic seizures and a shortened life span. Immunohistochemistry revealed a loss of PV+ neurons in the hippocampus and the layer V/VI of the somatosensory cortex without detectable morphological changes. Field potential recordings showed altered short and long-term plasticity and a switch from increased inhibition at 8 weeks to enhanced excitation at 21 weeks. In vivo studies suggested increased anxiety and a significant delay of PTZ induced seizures in KO mice. This study suggests a role of KCC2 for proper Cl ̄ homeostasis in PV+ interneurons and impressively showed how impairment in GABAergic inhibition contributes to balanced brain activity. Furthermore, our results demonstrate a role of PV+ interneurons for the stress axis, neuronal excitability and higher brain functions like learning and memory.

Young ones will love learning to count backwards as they watch five touchable ladybugs disappear one by one.