New Releases by Melanie Gerth

Ion homeostasis is essential for proper neuronal function, since changes in intra- or extracellular ion concentrations can cause neuropathological conditions including seizures and neuropathic pain. The Clˉ gradient determines the strength and polarity of GABAergic neurotransmission. It is established by the activity of cation-chloride cotransporters (CCCs), the K+-Clˉ co-transporter 2 (KCC2) and the Na+-K+-2Clˉ co- transporter 1 (NKCC1). To investigate how changes in Clˉ concentration in inhibitory neurons affect GABAergic neurotransmission and overall excitability, KCC2 expression was inhibited in parvalbuminergic (PV+) interneurons of C57BL/6 mice. KO mice showed an ataxic gait, spontaneous epileptic seizures and a shortened life span. Immunohistochemistry revealed a loss of PV+ neurons in the hippocampus and the layer V/VI of the somatosensory cortex without detectable morphological changes. Field potential recordings showed altered short and long-term plasticity and a switch from increased inhibition at 8 weeks to enhanced excitation at 21 weeks. In vivo studies suggested increased anxiety and a significant delay of PTZ induced seizures in KO mice. This study suggests a role of KCC2 for proper Cl ̄ homeostasis in PV+ interneurons and impressively showed how impairment in GABAergic inhibition contributes to balanced brain activity. Furthermore, our results demonstrate a role of PV+ interneurons for the stress axis, neuronal excitability and higher brain functions like learning and memory.

Negen bijtjes hebben het te druk om met de boerderijdieren te spelen. Prentenboek in oblong formaat met felgekleurde tekeningen en uitsparingen waardoor de bijen voelbaar zijn. Vanaf ca. 2,5 jaar.

Young ones will love learning to count backwards from nine to one as touchable, squeaky rubber ducks race down a river.

Young readers will love learning to count in this illustrated adaptation of a well-known nursery rhyme. Watch as each of the five plush, touchable ducklings disappears one by one

From Little Scholastic comes this innovative and interactive book for toddlers of things on the go! Ages: 2-3. This fully interactive book of vehicles will keep little hands busy: pull-tabs, lift-the-flaps, touch-and-feels, and holographic foil makes learning about things that go fun for hours! Ages: 2-3. Introducing Little Schoalstic, a developmental publishing program of interactive boks created exclusively to give babies and toddlers a head start in learning. Every book features: * Interactive components * High color contrast * Rhyming, repetitive, or predictable text * Familiar subjects and surroundings * Simple concepts * Distinct leveling between the ages of 0-3 years

C''est tellement rigolo d''apprendre à compter grâce à cinq canetons tout doux qui disparaissent au fil des pages.

Colorful touch-and-feel images hide behind sturdy cardboard flaps, sliding parts, and pop-ups, keeping little fingers busy while teaching the concept of shape in this interactive primer. Un colage de coloridas imagenes para tocar-y-sentir escondidas detras de resistentes solapas de carton, partes deslizables y otras que aparecen, mantienen ocupados a los pequenos deditos mientras ensena todo sobre las formas.

Con este libro los niños pueden aprender a contar al revés de 10 a 1 las mariquitas plásticas que aparecen en las ventanas de las páginas. Una por una las mariquitas se van cuando entra otro animal.

A vos marques ! Prêts ! Partez ! Les bolides viennent de s''élancer. Toi aussi installe-toi au volant, et devine qui sera l''heureux gagnant ! Un livre ludique, animé de neuf voitures en relief et d''un " Vroum, vroum ! " entraînant, pour découvrir les couleurs et l''ambiance des circuits.

Tien kleine elfjes verdwijnen in een sterrenregen een voor een naar Dromenland. Prentenboek met kleurrijke tekeningen en een tekst op rijm. Vanaf ca. 3 jaar.

Un livre pour tout apprendre sur la grande famille des dinosaures... Des matières à toucher, des animations, des caches et même une visite au musée dans la galerie des dinosaures !

Imágenes, colores, texturas, lengüetas, solapas... mirar, tocar, leer, jugar... Todo es posible con estos libros de gran formato si queremos conocer los vehículos, los colores, los números, las formas y los dinosaurios. Una colección de libros repletos de diversión para los más pequeños.

Young ones will love learning to count backwards as they watch five touchable ladybugs disappear one by one.

Words are paired with shapes featuring texture, pop-ups, flaps to lift, and pull tabs.

Enhanced with pop-ups, pull-the-tabs, and bright illustrations, an oversized novelty book provides preschoolers with a fun-filled guide to the era of the dinosaurs.

A creative new way to learn colors and first words Each book focuses on a favorite color, showing a variety of appealing images in the featured color. Children will learn to identify the color and the object as they pull tabs, lift flaps, and feel textures.

Five raised ladybugs disappear one by one as they try to make their way home. On board pages.

Illustrates a variety of transportation vehicles including trucks, cars, boats, trains, and planes.

With "touch and feel" textures, holographic foil, sturdy cardboard flaps, and movable parts on every spread, these books offer children interactive fun and learning! With warm, woolly scarves to touch, brightly coloured ornaments to hang on a giant pop-up tree, and much more, this jumbo book is the perfect way to celebrate Christmas!

Young ones will love learning to count backwards as they watch five touchable ladybugs disappear one by one.

Pour apprendre à compter jusqu''à 10, tu découvriras pour chaque chiffre : des devinettes, des animations, des matières à toucher et plein d''autres surprises !