Most Popular Books by Maria Rius

Aquest conte és el quart de la col·lecció «Ciutat i natura». A través del text i les il·lustracions descobrirem les meravelles del Parc Natural de Sant Llorenç del Munt i l’Obac: pedres amb llegenda, coves i moltes coses més. Tot d’una forma divertida i didàctica.

Brief text and illustrations explain the properties of fire, its uses, and its dangers.

Abstract: Decitabine (5-aza-2′-deoxycytidine) is a DNA methyltransferase inhibitor and an archetypal epigenetic drug for the therapy of myeloid leukemias. The mode of action of decitabine strictly depends on the incorporation of the drug into DNA. However, DNA incorporation and ensuing genotoxic effects of decitabine have not yet been investigated in human cancer cell lines or in models related to the approved indication of the drug. Here we describe a robust assay for the quantitative determination of decitabine incorporation rates into DNA from human cancer cells. Using a panel of human myeloid leukemia cell lines we show appreciable amounts of decitabine incorporation that closely correlated with cellular drug uptake. Decitabine incorporation was also detectable in primary cells from myeloid leukemia patients, indicating that the assay is suitable for biomarker analyses to predict drug responses in patients. Finally, we also used next-generation sequencing to comprehensively analyze the effects of decitabine incorporation on the DNA sequence level. Interestingly, this approach failed to reveal significant changes in the rates of point mutations and genome rearrangements in myeloid leukemia cell lines. These results indicate that standard rates of decitabine incorporation are not genotoxic in myeloid leukemia cells

The wolf gives his own outlandish version of what really happened when he tangled with the three little pigs.

The following thesis presents a stability study of a floating wind turbine platform, composed by two concentric cylinders, for offshore application. The theoretical bases of the linear theory and the derivation of the equation of motion are introduced in the second chapter. The following chapter resumes the results of the research of the optimum dimensions as well as the results of the simulation of the equation of motion of the spar with and without inertial plate. The addition of the inertial plate and the variation of its porosity (depending on the frequency of the incident wave) help to stabilize the structure in a large frequency bandwidth, due to the increment of the added mass coefficient and the consequent reduction of the resonance frequency. With the collaboration of the Centre of Nanotechnology and Smart Materials, CeNTI, a solution to simulate the porosity of the inertia plate is proposed as well as the material for the body of the spar and the plate and all the necessary corrosion treatments due to the seawater. Finally, the future work and all the conclusions of the study are explained in the last chapter.