Best Selling Books by Kim Baker

Simple blank dot grid journal for writing and planning.

A simple dotted grid journal to use for tracking and writing.

Girlfriend 101 is a dating and relationship book for women about how past baggage can get stuck and cause blocks in our relationships. Drawn from research, soul truths, and stories to Girlfriend 101 offers 7 ways we can drop the baggage and be more empowered in our lives and have more authentic relationships.

An inspirational self-help guidebook and journal that ultitizes prompts, original art, and recipes.

Have you always wondered what your animal is thinking, or wanted to know why s/he acts a certain way? Then look no further as "Quick How-To Guide for Learning to Talk with Animals" is your answer. This book offers detailed instructions on how to connect and communicate with animals. Don''t know what to ask your animal? This book provides suggested questions to ask your animal. Have an animal that is sick, lost or dying? This book guides you through advanced forms of communication, along with practice exercises to help build your confidence. Animal Communication and Intuitive Communication with Animals, learn how with this great book. The animals are talking. Are you listening? With this passionately and carefully written work by life-long animal communicator Kim Baker, you can and will hear them. Everyone has the ability to talk with animals. Everyone has intuitive abilities. We''re born with it. Just like the ability to sing. Everyone can sing, it''s just some people are better than others. The same is true of animal communication. It''s a muscle; the more you use it the better you become. Learn what animal communication is all about. Kim''s book offers a step by step process for communicating with animals. Practice exercises, troubleshooting techniques, and advanced forms of communication are all included in this excellent how-to guide. Joyce Leake, Communicating with Animals since 1994 and Founder of Animal University, says "I personally recommend this work as your entry to explore and satisfy whatever pathway it presents. As you open this channel you will quickly discover that the animals will counsel, advise and support you as you step into your own journey. As a communicator myself, I am aware of students'' needs and questions. Kim has skillfully addressed many in this very detailed work."

Simple blank dot grid journal for writing and planning.

Get in the mood for all things autumn with this simple dotted grid journal!

A PLANNER FOR BOOK LOVERS LIST NEW RELEASES AND YOUR TBR 52 BOOK REVIEW PAGES INCLUDED - 1 FOR EACH WEEK! 10 EXTRA PAGES FOR NOTES Use the planner for your normal day-to-day life, but with custom sections for your bookish planning.

A simple lined journal to record your thoughts about bacon - non-bacon thoughts is okay, too.

BLANK LINED JOURNAL A funny simple lined journal for all the bacon lovers out there. Also good to give to another fellow bacon lover.

Offers IBM-PC and compatible computer users the equivalent desktop publishing power that 50,000-plus Macintosh users have. Professional desktop publishers and QuarkXPress experts provide step-by-step instructions so you can master this popular new program. Fully explains set-up options, tools and menus, typographic controls, advanced applications and much more. Also contains over 100 illustrations.

BASIC 6-MONTH (26 WEEK) DAILY PLANNER BLANK DATES You can start whenever you want! WEEK AT A GLANCE Week at a glance page at the beginning of each week. DOT GRID PAPER Dotted grid paper at the end of each week plus extra in the back to journal and create custom pages! GREAT FOR PLANNER BEGINNERS! TRY OUT A PLANNER WITHOUT THE BIG INVESTMENT! SIMPLE AND HASSLE FREE!

A simple blank dotted-grid journal.

Surface Plasmon Resonance (SPR) is a biophysical technique that is able to measure molecular binding interactions in real time. Utilizing a Biacore 8K SPR instrument and Insight Evaluation Software (GE Healthcare), it is possible to analyze the dynamics of the molecular interactions between small molecule inhibitors to protein arginine methyltransferase-5 (PRMT5); an enzyme responsible for the symmetric dimethylation of arginine residues of both histone and non-histone proteins. PRMT5 has been implicated in a wide variety of cancers including ovarian, lung, and lymphoid cancers. Studies have also linked the overexpression of PRMT5 with poorer prognosis and survival. PRMT5''s methyltransferase function has attracted interest in developing selective inhibitors targeting the SAM-binding pocket and the substrate-binding pocket of PRMT5 in developing drugs to treat certain cancers. Reaction Biology Corp. has produced three small molecule inhibitors,VY-5-173, VY-5-177, and VY-5-178, designed to target the substrate-binding pocket of PRMT5 in developing proteolysis-targeting chimeras (PROTACs) molecules. PROTACs are an emerging platform that mediates the selective degradation of target proteins. In this work, the binding behaviors and kinetics of VY-5-173, VY-5-177, and VY-5-178 were compared to known small molecule inhibitors, EPZ015666, LLY-283, and JNJ-64619178, against PRMT5 using distinct binding modes in four different conditions. Measurements were conducted on the Biacore 8K in the absence and presence of cofactors MTA, SAH, and SAM to probe for competition and/or cooperativity that would provide insight into the binding modes of the small molecule inhibitors. Based on the SPR data, VY-5-173, VY-5-177, and VY-5-178 bind preferentially to cofactor bound PRMT5 with a difference of 100-fold: low- micromolar KD in MTA-bound PRMT5, mid-nanomolar KD in SAH-bound PRMT5, and high-picomolar KD in SAM-bound PRMT5. Among all of the buffer conditions assayed using SPR, the results demonstrate that compounds VY-5-173, VY-5-177, and VY-5-178 each bind SAM-bound PRMT5 with the highest affinity denoted by picomolar KDs, slow off-rates, and nanomolar highest starting concentrations. The kinetics and binding behaviors of VY-5-173, VY-5-177, and VY-5-178 closely resemble the binding modes of EPZ015666 as SAM-cooperative compounds; an analogue of EPZ015666 is currently in clinical trials for the treatment of solid tumors and non-Hodgkin''s Lymphoma.

Recommends that computer technologies should be applied to direct marketing through telephones, lists, graphic design, research, and videos

The first guide to using PCs to create and process color for print. Color Publishing on the PC introduces the power of new color technologies and explains the mechanics of producing color publications on IBM PCs and compatibles.

A simple blank dotted-grid journal.