New Releases by Kim Baker

A quirky, empowering story about a boy recovering from a bear attack with the help of his friends and, maybe, some magic. For fans of Unusual Chickens for the Exceptional Poultry Farmer by Kelly Jones and The Canning Season by Polly Horvath. Newt Gomez has a thing with bears. Having survived a bear attack last year, he now finds an unusual bear statue. Newt''s best friend thinks the statue grants wishes. But even as more people wish on the bear and their wishes come true, Newt is not a believer. But Newt has a wish too: while he loves his home on eccentric Murphy Island, he wants to go to middle school on the mainland, where his warm extended family lives. There, he''s not the only Latinx kid, and he won''t have to drive the former taco truck--a gift from his parents--or perform in the talent show. Most importantly, on the mainland, he never has bad dreams about the attack. Newt is almost ready to make a secret wish when everything changes. Tackling themes of survival and self-acceptance, Newt''s story illuminates the magic in our world, where reality is often uncertain but always full of salvageable wonders.

Surface Plasmon Resonance (SPR) is a biophysical technique that is able to measure molecular binding interactions in real time. Utilizing a Biacore 8K SPR instrument and Insight Evaluation Software (GE Healthcare), it is possible to analyze the dynamics of the molecular interactions between small molecule inhibitors to protein arginine methyltransferase-5 (PRMT5); an enzyme responsible for the symmetric dimethylation of arginine residues of both histone and non-histone proteins. PRMT5 has been implicated in a wide variety of cancers including ovarian, lung, and lymphoid cancers. Studies have also linked the overexpression of PRMT5 with poorer prognosis and survival. PRMT5''s methyltransferase function has attracted interest in developing selective inhibitors targeting the SAM-binding pocket and the substrate-binding pocket of PRMT5 in developing drugs to treat certain cancers. Reaction Biology Corp. has produced three small molecule inhibitors,VY-5-173, VY-5-177, and VY-5-178, designed to target the substrate-binding pocket of PRMT5 in developing proteolysis-targeting chimeras (PROTACs) molecules. PROTACs are an emerging platform that mediates the selective degradation of target proteins. In this work, the binding behaviors and kinetics of VY-5-173, VY-5-177, and VY-5-178 were compared to known small molecule inhibitors, EPZ015666, LLY-283, and JNJ-64619178, against PRMT5 using distinct binding modes in four different conditions. Measurements were conducted on the Biacore 8K in the absence and presence of cofactors MTA, SAH, and SAM to probe for competition and/or cooperativity that would provide insight into the binding modes of the small molecule inhibitors. Based on the SPR data, VY-5-173, VY-5-177, and VY-5-178 bind preferentially to cofactor bound PRMT5 with a difference of 100-fold: low- micromolar KD in MTA-bound PRMT5, mid-nanomolar KD in SAH-bound PRMT5, and high-picomolar KD in SAM-bound PRMT5. Among all of the buffer conditions assayed using SPR, the results demonstrate that compounds VY-5-173, VY-5-177, and VY-5-178 each bind SAM-bound PRMT5 with the highest affinity denoted by picomolar KDs, slow off-rates, and nanomolar highest starting concentrations. The kinetics and binding behaviors of VY-5-173, VY-5-177, and VY-5-178 closely resemble the binding modes of EPZ015666 as SAM-cooperative compounds; an analogue of EPZ015666 is currently in clinical trials for the treatment of solid tumors and non-Hodgkin''s Lymphoma.

A PLANNER FOR BOOK LOVERS LIST NEW RELEASES AND YOUR TBR 52 BOOK REVIEW PAGES INCLUDED - 1 FOR EACH WEEK! 10 EXTRA PAGES FOR NOTES Use the planner for your normal day-to-day life, but with custom sections for your bookish planning.

Simple blank dot grid journal for writing and planning.

Simple blank dot grid journal for writing and planning.

A simple blank dotted-grid journal.

A simple blank dotted-grid journal.

A simple dotted grid journal. Perfect for planning, journaling, and list-making!

A simple dotted grid journal. Perfect for planning, journaling, and list-making!

Get in the mood for all things autumn with this simple dotted grid journal!

BASIC 6-MONTH (26 WEEK) DAILY PLANNER BLANK DATES You can start whenever you want! WEEK AT A GLANCE Week at a glance page at the beginning of each week. DOT GRID PAPER Dotted grid paper at the end of each week plus extra in the back to journal and create custom pages! GREAT FOR PLANNER BEGINNERS! TRY OUT A PLANNER WITHOUT THE BIG INVESTMENT! SIMPLE AND HASSLE FREE!

An 8-week vacation plan with extra day trip itenerary pages! INCLUDES: WEEKLY VACATION PLAN which includes: who''s going? list, packing list, week-at-a-glance, and daily agenda. DAY TRIP ITENERARIES up to 20 trips. DOT GRID PAGES to write down additional information and notes. Great for families, couples, or individuals! The planner is small enough to throw in a bag so you can have it wherever you go!

Get in the mood for all things autumn with this simple dotted grid journal!

A journal in calming colors to write out all your thoughts.

BLANK LINED JOURNAL A funny simple lined journal for all the bacon lovers out there. Also good to give to another fellow bacon lover.

A simple lined journal to record your thoughts about bacon - non-bacon thoughts is okay, too.

A simple lined journal to record your thoughts and pass time on those lazy days.

Be wild and free, sit in a flower meadow and record your thoughts in this simple lined journal.

Girlfriend 101 is a dating and relationship book for women about how past baggage can get stuck and cause blocks in our relationships. Drawn from research, soul truths, and stories to Girlfriend 101 offers 7 ways we can drop the baggage and be more empowered in our lives and have more authentic relationships.

Of all the topics I have written about over the past 8 years, none have had more interest and started more conversations than the topic of dating red flags. Perhaps it''s because we are all a little too hard on ourselves when we look back on past relationships and think, "What the hell was I thinking?". Whatever the reason, we have all grown from what can only come from life''s hardest lessons in dating and in love. In this mini book I have gathered components of my writing about red flags from my book, Girls'' Guide to Healthy Dating: Between the Breakup and the Next U-Haul, as well as articles, posts, and some new pieces. My hope is that by providing a small book that looks specifically at dating red flags that my own experience may help you know you are not alone. After all, it''s our shared experiences that connect us all.

Kim Baker''s groundbreaking lesbian dating guide, Girls'' Guide to Healthy Dating: Between the Breakup and the Next U-Haul, answers the age old question we have when we find ourselves single again: Now what? Girls'' Guide to Healthy Dating transforms dating from an exasperating pattern of breaking up then U-Hauling rapidly into another relationship to a model for connecting with other women from a place of balance and authenticity. If you''re a lesbian who wants to transform dating from a frustrating search for the right one to adventures in getting to know women to identify compatibility, then this book is for you. For ages, women have gathered around restaurant tables with friends to begrudge the perils of dating as a lesbian. We don''t know how to date. We relationship hop. We don''t process our past relationships. Unlike other dating advice books where a relationship expert imparts knowledge on to the reader, Kim Baker uses a Sex in the City laid back voice to explore six powerful strategies for revolutionizing how we search for the woman of our dreams. Drawn from mindfulness and the law of attraction, Girls'' Guide to Healthy Dating unveils what we intuitively already know: if we really want to change our dating experience, we have to change the way we approach dating. By focusing on getting to know women to identify compatibility, we create more healthy dating experiences, are more likely to notice red flags and deal breakers, and ultimately are more likely to find the one. ...Very good advice for any lesbian who has ever had her heart broken and wants to move on to a new life in dating. - Lynda Many of the concepts in the book go beyond lesbian dating. - Jennifer W. I really enjoyed your voice because you showed vulnerability but ultimately come from a position of strength. -Julie P.

2014 QuillsEdge Press On The Edge poetry chapbook winner

Long day at work? Nothing in the house to make for dinner? Kim Baker, working professional and long-time cook, offers recipes and insight for you to create a terrific dinner any night of the week. Health-conscious recipes, ideas for creative improvisation, and a dose of fun make this book one of a kind. The book, which includes recipes for a variety of main dishes, sides, and easy-to-make desserts, will become your go-to guide for the workweek. It offers ideas and recipes that transform leftovers and make side dishes into star meals. It also includes a Pantry DiveTM chapter that reinvents the possibilities of the cupboard to create delicious meals from basic ingredients kept on-hand. As a single working mother, Kim understands the pressure that can accompany mealtime and that everyone has their own unique challenges to manage. The book has easy and delicious recipes that will inspire you. Kim has been featured in national and regional news outlets as she has taught working men and women about the accessibility of weeknight cooking. She has conducted demonstrations and events at corporate offices and in partnership with well-known brands. If you think you have too much on your plate to fully embrace the kitchen or you simply want to elevate your evening meal, try this book.

Have you always wondered what your animal is thinking, or wanted to know why s/he acts a certain way? Then look no further as "Quick How-To Guide for Learning to Talk with Animals" is your answer. This book offers detailed instructions on how to connect and communicate with animals. Don''t know what to ask your animal? This book provides suggested questions to ask your animal. Have an animal that is sick, lost or dying? This book guides you through advanced forms of communication, along with practice exercises to help build your confidence. Animal Communication and Intuitive Communication with Animals, learn how with this great book. The animals are talking. Are you listening? With this passionately and carefully written work by life-long animal communicator Kim Baker, you can and will hear them. Everyone has the ability to talk with animals. Everyone has intuitive abilities. We''re born with it. Just like the ability to sing. Everyone can sing, it''s just some people are better than others. The same is true of animal communication. It''s a muscle; the more you use it the better you become. Learn what animal communication is all about. Kim''s book offers a step by step process for communicating with animals. Practice exercises, troubleshooting techniques, and advanced forms of communication are all included in this excellent how-to guide. Joyce Leake, Communicating with Animals since 1994 and Founder of Animal University, says "I personally recommend this work as your entry to explore and satisfy whatever pathway it presents. As you open this channel you will quickly discover that the animals will counsel, advise and support you as you step into your own journey. As a communicator myself, I am aware of students'' needs and questions. Kim has skillfully addressed many in this very detailed work."

There is a complex and contested terrain of cultural heritage in the library, archive and museum context. Information Literacy and Cultural Heritage explores this landscape and covers perspectives from museums, archives and libraries, highlighting the role of memory and contested history in the collection, description and presentation of cultural heritage. The book argues that the convergence of libraries, archives and museums in digital preservation should be extended to include the development of combined lifelong learning programmes, teaching both information literacy skills and awareness of cultural heritage.This title is structured into seven chapters, covering cultural heritage in the library, archive and museum context; digital information contexts; an overview of information literacy models of stages and processes, as well as models of standards, competencies and performance indicators. The book then examines the role of critical thinking and lifelong learning; proposes a generic model of information literacy and cultural heritage for lifelong learning; offers guidelines for adapting the model to local contexts; and offers a conclusion. - Covers cultural heritage in the museums, archives and library context - Explores the place of cultural heritage and social issues in the digital information context - Reviews existing models of information literacy processes, standards and indicators

Do you desire a better relationship with your horse? Does your horse walk all over you? Want to put a great foundation on your young horse? "Groundwork Essentials: Foundation that Lasts a Lifetime" is a wonderful way to build trust with your horse, gain each other''s respect, establish you as your horse''s leader, create a working partnership, and ultimately develop a lasting relationship with your horse. These exercises work for young horses and older horses alike. Kim Baker walks you through each exercise and how to break it down to teach to your horse. She also tells you why each exercise is important and how it impacts your horse''s life for the better. Teach your horse not to pull back when tied and learn to trailer load with ease. Join us as we embark on a journey to a better relationship with our horses.

This is the story of love and survival. A barn cat''s fiery spirit to stay in this world, and a woman''s lifelong journey of understanding, overcoming resistance, and utilizing her personal gifts of working with, talking with, and healing animals.

Using a bogus name, the League of Picklemakers, sixth-grader Ben and three recruits start a prank-pulling club and receive funding from their middle school''s PTA. Illustrations.