New Releases by Heidi Schulz

Em 1938, na cidade de Boston, começou um dos mais extraordinários estudos científicos feitos até hoje sobre a felicidade. Um grupo de investigadores reuniu 456 rapazes de famílias desfavorecidas, todos com 14 anos, para tentar perceber por que razão estavam a resistir tão bem às contrariedades da vida; ao mesmo tempo, um segundo grupo decidiu estudar 268 alunos de Harvard – ou seja, pessoas que, pela sua educação e privilégio, prometiam tornar-se bem-sucedidas (basta referir que uma delas se chamava... John F. Kennedy). Os dois grupos acabaram por fundir-se no hoje famoso Estudo de Harvard sobre o Desenvolvimento Adulto. Os participantes originais (bem como os seus filhos e netos) foram acompanhados passo a passo, ao longo de 84 anos (!), e as suas histórias foram tratadas, analisadas e cruzadas com outros estudos científicos, sempre à procura de uma resposta: qual é a chave para Uma Boa Vida? De acordo com os professores catedráticos Robert Waldinger e Marc Schulz, os atuais diretores do estudo, a saúde e a felicidade não se alimentam do sucesso financeiro ou profissional, mas sim da qualidade das nossas relações pessoais.

Library anxiety is a significant problem that affects a considerable number of individuals, particularly those with disabilities. Unfortunately, public libraries often overlook this issue, leading to patrons feeling unwelcome or intimidated when attempting to utilize library resources and services. This can ultimately discourage them from visiting the library altogether. However, libraries can guarantee that everyone has the same access to information and resources by prioritizing accessibility and delivering outstanding customer service to all patrons. Libraries must acknowledge the importance of addressing library anxiety and take action to establish an inclusive environment that welcomes all members of the community. By doing so, libraries can achieve their goal of providing access to information and promoting lifelong learning for all.

Abstract: A significant portion of patients diagnosed with vitelliform macular dystrophy (VMD) do not carry causative mutations in the classic VMD genes BEST1 or PRPH2. We therefore performed a mutational screen in a cohort of 106 BEST1/PRPH2-negative VMD patients in two genes encoding secreted interphotoreceptor matrix proteoglycans-1 and -2 (IMPG1 and IMPG2). We identified two novel mutations in IMPG1 in two simplex VMD cases with disease onset in their early childhood, a heterozygous p.(Leu238Pro) missense mutation and a homozygous c.807 + 5G u003e A splice site mutation. The latter induced partial skipping of exon 7 of IMPG1 in an in vitro splicing assay. Furthermore, we found heterozygous mutations including three stop [p.(Glu226*), p.(Ser522*), p.(Gln856*)] and five missense mutations [p.(Ala243Pro), p.(Gly1008Asp), p.(Phe1016Ser), p.(Tyr1042Cys), p.(Cys1077Phe)] in the IMPG2 gene, one of them, p.(Cys1077Phe), previously associated with VMD. Asymptomatic carriers of the p.(Ala243Pro) and p.(Cys1077Phe) mutations show subtle foveal irregularities that could characterize a subclinical stage of disease. Taken together, our results provide further evidence for an involvement of dominant and recessive mutations in IMPG1 and IMPG2 in VMD pathology. There is a remarkable similarity in the clinical appearance of mutation carriers, presenting with bilateral, central, dome-shaped foveal accumulation of yellowish material with preserved integrity of the retinal pigment epithelium (RPE). Clinical symptoms tend to be more severe for IMPG1 mutations

Fresh off a fearsome encounter with the Neverland crocodile, Jocelyn Hook decides the most practical plan is to hunt down her father''s famous fortune. After all, she''ll need the gold to fund her adventuring in the future. (And luckily, Hook left her the map.) But the map proves to be a bit harder to crack than Jocelyn had hoped, and she''s convinced that the horrible Peter Pan might be the only one with the answers. Of course, he doesn''t really feel like helping her, so Jocelyn takes the only reasonable course of action left to her: she kidnaps his mother. Evie, though, is absolutely thrilled to be taken prisoner, so Jocelyn''s daring ploy doesn''t have quite the effect she''d planned for. Along with the problem of her all-too-willing captive, Jocelyn must also contend with Captain Krueger, whose general policy is that no deed is too dastardly when it comes to stealing Hook''s treasure. And with the ever-shifting Whens of the Neverland working against her as well, Jocelyn, Evie, Roger, and the rest of the Hook''s Revenge crew have their work cut out for them. In this rambunctious showdown between characters new and old, Jocelyn puts her own brand of pirating to the test in a quest to save her future and those she loves. Praise for Hook''s Revenge New York Times best-seller "A deliciously witty, delightfully inventive, devilishly fun adventure." -Anne Ursu, Longlisted for the National Book Award for The Real Boy * "Whether a fan of J.M. Barrie''s classic tale or new to Neverland, readers will be clamoring for more from this enchanting world." -School Library Journal, starred review * "Readers will delight both the story and the storytelling." -Bulletin of the Center for Children''s Books, starred review "Featuring a lively, colorful cast, and a droll narration with snarky asides by an anonymous, self-proclaimed pirate authority, this entertaining take on the Peter Pan story neatly blends action-adventure and comical and heartfelt moments." -Booklist Praise for The Pirate Code "An imaginative adventure filled with humor and heart." -Kirkus Reviews "[T]his delightful sequel successfully interweaves adventure, suspense, Peter Pan stories, pirate lore, humor, and heart." -Booklist "Here''s a book that''s funny and ferocious; an adventure with a heart of gold buried deep in its chest, told by one of the great unreliable narrators--unreliable in the sense that you wouldn''t want to ask him to watch your bike." --Adam Rex, New York Times best-selling author

In this mischievously funny picture book, friends come in all shapes and sizes. In case you were wondering, here''s an incomplete list of things giraffes ruin: - Birthday parties - Going to the movies - Playing at the park - Hide and Seek - Everything else Yes, that''s right. Giraffes ruin everything. But what happens when our narrator gets into a tricky situation? Perhaps he''ll find giraffes aren''t so bad after all . . .

Fresh off a fearsome encounter with the Neverland crocodile, Jocelyn Hook decides the most practical plan is to hunt down her father''s famous fortune. After all, she''ll need the gold to fund her adventuring in the future. (And luckily, Hook left her the map.) But the map proves to be a bit harder to crack than Jocelyn had hoped, and she''s convinced that the horrible Peter Pan might be the only one with the answers. Of course, he doesn''t really feel like helping her, so Jocelyn takes the only reasonable course of action left to her: she kidnaps his mother. Evie, though, is absolutely thrilled to be taken prisoner, so Jocelyn''s daring ploy doesn''t have quite the effect she''d planned for. Along with the problem of her all-too-willing captive, Jocelyn must also contend with Captain Krueger, whose general policy is that no deed is too dastardly when it comes to stealing Hook''s treasure. And with the ever-shifting Whens of the Neverland working against her as well, Jocelyn, Evie, Roger, and the rest of the Hook''s Revenge crew have their work cut out for them. In this rambunctious showdown between characters new and old, Jocelyn puts her own brand of pirating to the test in a quest to save her future and those she loves. Praise for Hook''s Revenge "Whether a fan of J.M. Barrie''s classic tale or new to Neverland, readers will be clamoring for more from this enchanting world." -- School Library Journal, starred review "Readers will delight both the story and the storytelling." -- Bulletin of the Center for Children''s Books, starred review "Featuring a lively, colorful cast, and a droll narration with snarky asides by an anonymous, self-proclaimed pirate authority, this entertaining take on the Peter Pan story neatly blends action-adventure and comical and heartfelt moments." -- Booklist

It''s not easy being the daughter of Captain Hook. Twelve-year-old Jocelyn dreams of following in his footsteps - but her grandfather sends her to finishing school instead. When her father meets his unfortunate end, Jocelyn sails to Neverland to avenge his death. But she hadn''t bargained on ticking crocodiles, lazy pirates and a troublemaking boy called Peter Pan.

Twelve-year-old Jocelyn dreams of becoming every bit as daring as her infamous father, Captain James Hook. Her grandfather, on the other hand, intends to see her starched and pressed into a fine society lady. When she’s sent to Miss Eliza Crumb-Biddlecomb’s Finishing School for Young Ladies, Jocelyn’s hopes of following in her father’s fearsome footsteps are lost in a heap of dance lessons, white gloves, and way too much pink. So when Jocelyn receives a letter from her father challenging her to avenge his untimely demise at the jaws of the Neverland crocodile, she doesn’t hesitate—here at last is the adventure she has been waiting for. But Jocelyn finds that being a pirate is a bit more difficult than she’d bargained for. As if attempting to defeat the Neverland’s most fearsome beast isn’t enough to deal with, she’s tasked with captaining a crew of woefully untrained pirates, outwitting cannibals wild for English cuisine, and rescuing her best friend from a certain pack of lost children, not to mention that pesky Peter Pan who keeps barging in uninvited. The crocodile’s clock is always ticking in Heidi Schulz’s debut novel, a story told by an irascible narrator who is both dazzlingly witty and sharp as a sword. Will Jocelyn find the courage to beat the incessant monster before time runs out?

Das Lehr- und Arbeitsbuch, jetzt in der 2., durchgesehenen Auflage, wendet sich an Lernende in Hotellerie und Gastronomie, die keine oder nur sehr geringe Kenntnisse der französischen Sprache mitbringen. Es verwendet den Grundwortschatz, wie er in der Berufspraxis gefordert wird und orientiert sich am aktuellen Sprachgebrauch. "Veuillez me suivre" vermittelt die wichtigsten grammatischen Strukturen und ermöglicht - dank des streng progressiven Aufbaus - auch Anfängern, sich in kurzer Zeit sprachlich zurechtzufinden. Fortgeschrittene können verschüttete Kenntnisse auffrischen und die Fachausdrücke der Gastronomie kennen lernen. Farbige Originalabbildungen historischer und heutiger Speisekarten aus Frankreich sowie humorvolle fach- und landeskundliche Texte lockern den anspruchsvollen Lehrstoff auf und bieten erhellende Einblicke in die französische Wesensart, den "esprit français".