Best Selling Books by Evan Thomas

"Dalam ""A Long Time Coming"", yang ditulis oleh Evan Thomas, Newsweek menyajikan kisah mendalam tentang pemilihan presiden Amerika 2008 yang bersejarah. Narasi menarik ini menampilkan bangkitnya Barack Obama, kembalinya John McCain, pertarungan panjang antara Obama dan Hillary Clinton, kemunculan Sarah Palin yang mengguncang, dan perjalanan akhir Obama menuju kemenangan. Narasi ini menawarkan gambaran mendetail tentang Clinton, McCain, dan Obama selama mereka bertarung, melewati saat-saat penuh frustrasi dan keraguan serta pertengkaran dengan keluarga dan penasihat mereka. Narasi ini mengungkapkan konflik dalam kampanye Clinton yang berantakan, keputusan McCain untuk mengubah strategi kampanye, juga cara Obama menjadikan dirinya pemimpin kampanye terbesar dan terbaik dalam sejarah politik Amerika."

Upon assuming the presidency in 1953, Dwight Eisenhower came to be seen by many as a doddering lightweight. Yet behind the bland smile and apparent simplemindedness was a brilliant, intellectual tactician. As Evan Thomas reveals in his examination of Ike''s White House years, he was a master of calculated duplicity. He could be patient and ruthless in the con, and generous and expedient in his partnerships. Facing the Soviet Union, China, and his own generals, some of whom believed a first strike was the only means of survival, Eisenhower would make his boldest and riskiest bet yet, one of such enormity that there could be but two outcomes: the survival of the world, or its end. This is the story of how he won.

Readers brought up on Hollywood westerns will have their eyes opened by this story of a working cowboy. Although he never chased a rustler or rescued a pretty girl and probably couldn''t even hire on as an extra in a B-grade western, Ed Alford (or "Fat") has worked cattle most of his life. Fred Gipson''s vivid, earthy book about this cowhand, now in paperback, tells what the job is really like, the hardships, the hell-raising, and the sheer monotony of daily tasks.Fat Alford became a cowboy because he didn''t think picking cotton was any way for a man to make a living. Although he may not have looked much like a cowboy and certainly started out green, he learned to rope a cow in an impenetrable brush, to break a mean horse, to get by with poor gear, worse food, and sorry mounts in freezing cold or blistering heat and still get the job done.Gipson''s warm and rousing account captures the vivid reality of how it was and introduces us to a remarkable character--a working cowhand. This new paperback edition of Cowhand is sure to delight a whole new generation of readers.

The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a revolution of its own: digitization of epic proportions to preserve these invaluable works in the largest archive of its kind. Now for the first time these high-quality digital copies of original 18th century manuscripts are available in print, making them highly accessible to libraries, undergraduate students, and independent scholars. Western literary study flows out of eighteenth-century works by Alexander Pope, Daniel Defoe, Henry Fielding, Frances Burney, Denis Diderot, Johann Gottfried Herder, Johann Wolfgang von Goethe, and others. Experience the birth of the modern novel, or compare the development of language using dictionaries and grammar discourses. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library T125272 Shrewsbury: printed by T. Wood, and sold by the booksellers in town and country, [1786?]. 27, [1]p.; 4°

Genesis has been defeated and Lloyd''s world is safe from Corruption! Lloyd, Zahna, and Earl, have all walked away from the War for the Sands of Time with their lives and new abilities, ready to finally put time-travel and multi-versal crisis behind them. Cyrus has officially assembled them as an "elite team" for the M.S.O. with a familiar figure joining them as well... Karina! Dozens of Entities have mysteriously rained down from space and the enormously powerful orbs are causing danger wherever they turn up. The team has their hands full with this problem and barely have time to notice something far worse lurking in the shadows. A new group of cultists and terrorists are leaving destruction in their wake and Cyrus is determined to discover who or what is behind them. And meanwhile, unbeknownst to anyone, a key figure from someone''s past is on a path that leads back to them... and when they arrive, nothing will be the same.

书名原文:The wise men six friends and the world they made

Ordinary kinds, K, admit of leeway, both in the number of things that must be arranged K-wise and even in what arrangements count as being arranged K-wise. Consider a chair. A slightly smaller collection of things in pretty much the same arrangement would presumably still be some things arranged chairwise and would count as a chair. But there are plausibly many such collections of things in the vicinity of any chair. Thus, it seems that I am seated in many chairs. This is an instance of the problem of the many.

Resiliency projects are being implemented throughout coastal communities with the intention of reducing the loss of salt marsh habitat. Salt marsh enhancement projects may have the benefit of minimizing physical coastal impacts, but enhancement activities are not fully understood as a result of potential impacts on salt marsh ecosystems, particularly nekton or fish and decapod communities. Questions involving salt marsh enhancement remain in regard to negative impacts on nekton communities and hydrologic habitat connectivity. To evaluate the impacts of salt marsh enhancement in reference to nekton community structures, I compared nekton density in restored and non-restored locations on two salt marshes in New Jersey. My results suggest that salt marsh thin-layer placement impacts habitat use, with some habitat features becoming lost for nekton during the initial construction phase. Specifically, greater density of decapods, particularly Palaemonetes pugio (daggerblade grass shrimp), were found post restoration, suggesting that their presence could represent early successional species providing unquestionable ecological importance for transporting energy and nutrients throughout multiple salt marsh trophic levels. Additionally, two years post salt marsh restoration, young of the year Cyprinodon variegatus (sheepshead minnow) and Fundulus majalis (striped killifish) were found utilizing restored salt marsh pools under severe biological thresholds such as low dissolved oxygen and elevated water temperature conditions. In future studies, greater emphasis should be focused on the initial oxygen availability in sediments. Regions exhibiting low oxygen concentrations may influence vegetative species composition and growth. Additionally, reestablishing vegetative cover to areas that receive excess dredged material may be critical to ensure the creation and enhancement of valuable coastal habitats. Lastly, ensuring hydrologic habitat connectivity (i.e., connecting tidal and subtidal creeks with restored salt marsh pools) before placement of dredged material is applied for thin-layer restoration, is critical to ensure maximum habitat availability for nekton species. Clearly, sea level rise can result in salt marsh loss along the coast and thin-layer placement can be used to counter these effects if properly planned and administered appropriately to address plant community restoration and nekton use.

This thesis describes the comprehensive planning effort undertaken by the Metropolitan Area Planning Council in the Boston area. This effort engaged over 4,000 of the area''s residents between 2002 and 2009 and produced a new vision and action plan for the region entitled ''MetroFuture,'' Without formal authority to ensure compliance with the plan, the agency worked to increase the scale, transparency, and specificity of its efforts in order to build broad-based support for implementation. This study analyzes MAPC''s use of modeling, public participation, and advocacy and evaluates the strengths and weaknesses of the agency''s "new regionalism" approach. They were able to achieve more diverse participation, a more comprehensive plan, and actionable recommendations with input from a much broader set of actors than previous efforts. They were hampered by the lack of political endorsement from state and local leaders, as well as by financial constraints and their inability to secure stakeholder agreement on key recommendations. The concluding discussion makes recommendations to other metropolitan regions trying to re-think how best to conduct comprehensive regional planning efforts.

CTLA-4 and PD-1 are immune checkpoints that inhibit T cell activity to maintain immune homeostasis. These checkpoints have also emerged as highly validated cancer targets to stimulate immune responses against cancer. Despite the potential advantages of small molecule inhibitors have over antibodies, the discovery of small molecules that target the CTLA-4 or PD-1 checkpoints has greatly lagged behind the development of monoclonal antibodies. To discover small molecule inhibitors of the CTLA-4 and PD-1 signaling pathways, we have utilized a fragment-based approach. Fragment screens were conducted against CTLA-4, PD-1, and PD-L1 proteins to identify lead compounds for further optimization. While CTLA-4 and PD-1 fragment screens resulted in low hit rates and suboptimal start points, PD-L1 had a much higher hit rate and is likely druggable by small molecules. Fragments were identified that bind to PD-L1 at the PD-1 binding site and displace PD-1 using an NMR-based displacement assay. Co-crystal structures of these fragments bound to PD-L1 were obtained to facilitate structure-based design to develop more potent analogs. The fragment screening results and preliminary SAR discussed in this thesis serve as important starting points for the further development of novel small molecule-based checkpoint inhibitors.