Best Selling Books by David Kirk

Nova the Robot wants to build a new friend. Help him find the right color shapes to make his pet come to life!"--Cover back.

This is an up-to-date reference source on prostate, providing case histories, key points, questions, answers and practical tips for overcoming problems. It includes the latest advances in diagnosis and treatment as well as practical self-help advice and preventive measures. The book is one of a series on a wide range of medical and health issues which covers common complaints and illnesses, such as asthma and heart disease as well as more general health topics, such as nutrition and travel health. Addresses of useful organisations appear at the end of each book.

Best bug buddies for life! Join Bounce and his family on their fun packed adventures in Sunny Patch. Bursting with colouring fun and lots of activities to keep little bugs busy, this sticker story book includes an exciting cut-out bug mobile on the back cover.

Cilia are multifunctional organelles implicated in many human diseases. Cilia project from the cell surface and thus are well-situated for roles both in motility and sensory reception. The green alga Chlamydomonas reinhardtii is a useful model system for studies of cilia due to its combination of genetics, molecular biology, and biochemistry. At the base of cilia are modified centrioles called basal bodies, which are connected with cilia via a transition zone. Ciliary assembly and disassembly must be co-ordinated with cell cycle progression because the basal bodies must be freed in order to organize the mitotic spindle. Ciliary disassembly can occur either by deflagellation, a drastic stress response, or resorption, a gradual process normally occurring before cell division. I hypothesized that there might be commonality between the two pathways for ciliary loss. I discovered that cells with mutations in ciliary assembly invoke deflagellation in some circumstances, and resorption in others. Deflagellation mutants also exhibited resorption defects, supporting my hypothesis. To further explore the relationship between deflagellation and cell cycle, Qasim Rasi and I examined katanin, a microtubule-severing protein implicated in deflagellation in Chlamydomonas, and in mitosis in mammalian cells. A reverse genetics approach revealed that the only cells that can survive knock-down of katanin are mutants which already lack cilia. This led us to form the hypothesis that the role of katanin in the cell cycle is related to its cilia-severing activity. In support of this idea, I observed that wild-type cells entering mitosis sever their cilia to free the basal bodies. Katanin-mediated deflagellation is defective in fa2 mutants, and FA2 is a member of the Nek family of mitotic kinases. The Neks are a large family of kinases and through evolutionary analyses, Brian Bradley and I discovered that the family expanded early in eukaryotic evolution and it is likely that Neks co-ordinate the cycle of ciliary assembly and dissasemby with cell cycle progression. This study also identified the Chlamydomonas Nek CNK3 as an orthologue of the human disease gene Nek8, suggesting an avenue to further disease-related research.

Dragon learns a lesson when he pretends to be sick.

On Bug Your Mom Day in Sunny Patch, all the bugs get Miss Spider the best presents. When the gifts are ruined in an accident, the bugs must devise an alternative plan quickly.

Aujourd'hui, c'est jour de fête à Sunny Patch ! Frimousse, avec l'aide des enfants, décide de monter un spectacle à faire froid dans le dos. Pas si simple de mobiliser les troupes...

Spinner learns that having fun is the most important part of playing sports.

Cada dia son mas los hombres afectados por problemas de prostata; los sintomas y tratamientos disponibles se exponen detalladamente en este libro, asi como algunos casos clinicos reales y una seccion de preguntas y respuestas. En este volumen: Funciones de la prostata y posibles patologiasComo se diagnostican los problemas de prostataEl cancer de prostata y otros trastornosTratamientos que mejoran la calidad de vidaCasos clinicos

Elderly people are potentially at higher risk of gastroenteritis and foodborne diseases due to declining immunity, co-morbid illnesses and poorer food handling. In particular, residents of Long-Term Care Facilities (LTCF) have been highlighted as an 'at-risk' group, as outbreaks often occur in these facilities. The objectives of my research were to estimate the incidence of gastroenteritis and foodborne diseases in elderly Australians compared with other age groups, and elderly Australians living in LTCFs compared to elderly people in the community. I also examined the occurrence of outbreaks and causes of foodborne diseases in elderly people. To achieve these objectives I analyzed five different datasets: (1) a systematic review of gastroenteritis in LTCF residents, (2) 12-months longitudinal surveillance for gastroenteritis in residents of 16 LTCF in New South Wales, (3) two national surveys of gastroenteritis in the Australian community, (4) food- and waterborne infections in elderly people from Victorian public health surveillance, and (5) national surveillance of outbreaks of gastroenteritis and foodborne disease in Australian LTCF. I defined elderly people as 65 years or older. I analyzed datasets using meta-analysis, and negative binomial and logistic regression, depending on the nature of the data. In a meta-analysis of 15 international studies included in the systematic review, I estimated LTCF residents experience 0.15 episodes of gastroenteritis per person per year. Incidence was higher for studies conducted outside the United States at 0.27 episodes per person per year, which was similar to my findings of 0.23 episodes of diarrhea per person per year from longitudinal surveillance of 16 Australian LTCF. I estimated from national surveys that elderly people living in the community experienced 0.15 episodes of diarrhea per year, which was lower than any other age group. From Victorian surveillance data, the rate of Campylobacter infection in LTCF residents was 37% lower than in community residents, after adjusting for age, gender and reporting period. However, Victorian LTCF residents were at higher risk of Salmonella infections, particularly in association with outbreaks. From longitudinal surveillance, 96% (245/254) of gastroenteritis episodes in LTCF residents were outbreak-associated. Analysis of 3,257 outbreaks of gastroenteritis that occurred in Australian LTCF over six years identified that 84,769 people were affected and facilities could expect one outbreak every three years. Outbreaks were predominantly transmitted from one infected person to another, with norovirus causing 35% (1,136/3,257) of outbreaks. Foodborne outbreaks were extremely rare and a food-vehicle was only identified in 27% (14/52) of outbreaks, where the main causes were meals that were pureed or contained eggs. In outbreaks of foodborne salmonellosis, 6.1% (15/244) of affected LTCF residents died. It was surprising to find that elderly people do not experience more gastroenteritis than younger people. Elderly people living in LTCF had a lower incidence of many foodborne infections than those living in the community, with the exception of salmonellosis. Gastroenteritis in LTCF residents was often associated with outbreaks, which were mainly spread from person-to-person. From these studies, health agencies should focus on identifying interventions to contain outbreaks of viral gastroenteritis in LTCF.

This thesis represents research undertaken as part of a professional doctorate programme by a prison chaplain employed in Her Majesty's Prison and Probation Service. A pressing pastoral challenge at the time of fieldwork was the increased risk of self-harm and suicide amongst people in custody. This was especially true of those serving an indeterminate sentence of Imprisonment for Public Protection (IPP). The on-going deferral of the hope of release experienced by many IPP people in custody was identified as a significant factor that led to harmful levels of despair. An ethnographic enquiry was undertaken to ascertain how hope might be maintained amongst those serving this sentence. Qualitative data analysis of participant interviews identified seven meta-themes, with 'relationality' playing a key role in the maintenance of hope. As an exercise in Practical Theology this research offers a model of pastoral care that is broad and inclusive. The principles and practices enumerated here, whilst rooted in traditions of Christian theology, are offered in service of secular and plural discourses that constitute modern penal practice. In the field of Practical Theology this research provides a contribution to inter-disciplinary conversation and reflexive practice undertaken beyond ecclesial confines and at the margins of civic life. Further work by the author can be found at https://www.researchgate.net/profile/David-Beedon.