New Releases by Christos Papadimitriou

Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with a poor prognosis. Effective treatment with acceptable outcomes is yet to be found, with chemo- and radioresistance comprising major impediments towards this goal. Although upfront surgery is the established therapeutic approach for resectable and borderline resectable disease, neoadjuvant treatment has recently monopolized the interest in clinical trials. This also applies to locally advanced pancreatic adenocarcinomas that could potentially be rendered operable. Chemotherapy and chemoradiotherapy are the most utilized therapeutic modalities in the neoadjuvant setting, while immunotherapy and targeting agents have been gaining significant attention. This critical review focuses on the clinical experience gained from retrospective and phase II/III randomized trials, reporting on the outcomes of neoadjuvant chemotherapy and chemoradiotherapy for pancreatic adenocarcinoma. Moreover, the ongoing trials, including those that involve immunotherapy and targeting agents, are summarized.

This exceptional graphic novel recounts the spiritual odyssey of philosopher Bertrand Russell. In his agonized search for absolute truth, Russell crosses paths with legendary thinkers like Gottlob Frege, David Hilbert, and Kurt Gödel, and finds a passionate student in the great Ludwig Wittgenstein. But his most ambitious goal-to establish unshakable logical foundations of mathematics-continues to loom before him. Through love and hate, peace and war, Russell persists in the dogged mission that threatens to claim both his career and his personal happiness, finally driving him to the brink of insanity. This story is at the same time a historical novel and an accessible explication of some of the biggest ideas of mathematics and modern philosophy. With rich characterizations and expressive, atmospheric artwork, the book spins the pursuit of these ideas into a highly satisfying tale. Probing and ingeniously layered, the book throws light on Russell''s inner struggles while setting them in the context of the timeless questions he spent his life trying to answer. At its heart, Logicomix is a story about the conflict between an ideal rationality and the unchanging, flawed fabric of reality.

Livro texto que oferece aos estudantes uma sólida compreensão da química orgânica, privilegiando o enfoque no funcionamento dos mecanismos das reações, fundamental para o bom desenvolvimento da disciplina.

This volume contains the papers presented at the International Workshop on Internet and Network Economics held during December 17–20, 2008, in Sha- hai, China, for its fourth edition. WINE 2008 provided a forum for researchers from di?erent disciplines to communicate with each other and exchange their researching ?ndings in this emerging ?eld. WINE 2008hadteninvitedspeakers:FanChungGraham,MatthewJackson, Lawrence Lau, Tom Luo, Eric Maskin, Paul Milgrom, Christos Papadimitriou, Herbert Scarf, Hal Varian and Yinyu Ye. There were 126 submissions. Each submission was reviewed on average by 2. 5 Programme Committee members. The Committee decided to accept 68 papers. The programme also included 10 invited talks. This ?nal program contained papers covering topics including equilibrium, information markets, sponsored auction, network economics, mechanism - sign,socialnetworks,advertisementpricing,computationalequilibrium,network games, algorithms and complexity for games. December 2008 Christos Papadimitriou Shuzhong Zhang Organization Programme Chairs Conference Chair Herbert E. Scarf (Yale University) Program Co-chair Christos Papadimitriou (UC Berkeley) Program Co-chair Shuzhong Zhang (Chinese University of Hong Kong) Local Organizing Committee Chairs Committee Chair Yifan Xu (Fudan University) Committee Co-chair Duan Li (Chinese University of Hong Kong) Committee Co-chair ShouyangWang(ChineseAcademyofSciences) Committee Co-chair Xiaoping Zhao (SSE INFONET Ltd.

Abstract: "We introduce and study a novel genre of optimization problems, which we call segmentation problems. Our motivation, in part, is the development of a framework for evaluating certain data mining and clustering operations in terms of their utility in decision-making. For any classical optimization problem, the corresponding segmentation problem seeks to partition a set of cost vectors into several segments, so that the overall cost is optimized. This framework contains a number of standard combinatorial clustering problems as special cases, and many segmentation problems turn out to be MAXSNP-complete even when the corresponding ''un-segmented'' version is easy to solve. We develop approximation algorithms for two natural and interesting problems in this class -- the hypercube segmentation problem and the catalog segmentation problem -- and present a general greedy scheme, which can be specialized to approximate a large class of segmentation problems. Finally, we indicate some connections to local search, game theory, and sensitivity analysis in linear programming."