New Releases by Adam Bradley

Astrocytes are the primary cell type of the human brain and are important for its normal development and function as well as the pathogenesis of various neurological diseases. As such, astrocytes are an important target for therapeutic intervention and investigations into their function are important for understanding the functioning of the brain. Human astrocytes display numerous differences from those of rodents and other non-human primates. Additionally, astrocytes display differential morphologies and expression of key genes between different anatomical regions. Here, I have developed two systems for the investigation of human astrocyte functions utilizing human embryonic stem cells (hESCs) and the CRISPR/Cas9 gene editing technology. I found important gene expression and functional differences between astrocytes patterned to different regions of the brain and spinal cord. Astrocytes are important for the formation of the blood-brain barrier (BBB) as well as support the maturation neurite outgrowth of neural progenitors. I show that regional astrocytes achieve these functions to different degrees and their ability to support neuronal maturation is dependent on the regional identity of the neurons they are in contact with. Additionally, gene expression differences between regional astrocytes can be shown to have functional outcomes in intracellular calcium signaling and BBB tightening. Perturbing the function of these genes are shown to induce differential functions. Thus the developmental origin of astrocytes is important for their gene expression profiles and interaction with other cell types. The function of naïve astrocytes is important for establishing innate differences between astrocyte populations but is incapable of assessing the effect of neurons and other cell types on astrocyte function. Astrocytes develop after the bulk of neurogenesis is completed in the CNS and it is doubtful that there are ever any truly naïve astrocytes during development. The input of neurons and other cell types including oligodendrocytes and endothelial cells of the vasculature will certainly impact astrocyte gene expression and function. Fully understanding the function of astrocytes human as they exist in vivo will require techniques for assaying transcriptomic differences in astrocytes when cultured with other cell types and in various conditions. To this end I developed a system which utilizes thiouracil tagging technology for the investigation of astrocyte-neuron cocultures under varying conditions. The use of RNA-tagging technologies can allow for the investigation of cell type-specific transcriptional changes in situ without the need for the separation of cells prior to analysis. Thiouracil tagging of nascent RNA in the presence of 4-thiouracil (4TU) and Toxoplasma gondii uracil phosphoribosyltransferase (TgUPRT) allows for RNA-tagging with both the cell-type and temporal control of labeling, permitting a greater range of applications over previous RNA-tagging technologies. By utilizing TgUPRT expressing astrocytes in culture with neurons expressing designer receptors activated exclusively by designer drugs (DREADDs), which are capable of specifically activating or inhibiting neuronal activity, I assayed gene expression changes in astrocytes while cultured with activated or inhibited neurons. Astrocytes display large gene expression changes in response to neuronal activity including gene important for metabolism, synaptic regulation by astrocytes as well as genes implicated in Alzheimer''s disease pathogenesis. Taken together, I have discovered that regional astrocytes display gene expression and functional differences that are important for the normal development and functioning of the brain and developed a system for analysis of transcriptomic changes in astrocytes when cultured with other cell types under dynamic conditions.

People prefer methods that involve subjectively easier and faster processing fluency, and emphasize performance when making judgments about their learning. Studying cue-target pairs feels much easier than seeing a cue and laboring to retrieve an answer, and reading words in larger and clearer fonts feels easier. When people see information (like logos or flags) very often, they tend to think that they are easier to remember and consistently bias their confidence upward. The first set of studies (Chapter 2) examines a current debate in metamemory research regarding the roles of fluency (Rhodes & Castel, 2008a) and belief cues (Mueller, Dunlosky, Tauber, & Rhodes, 2014) in the construction of judgments of learning (JOLs). The results provide clear confirmatory evidence for the effects of belief on JOLs, though these data neither support a pure fluency hypothesis nor a pure belief-based hypothesis. I discuss an additive effect of perceptual fluency and belief on JOLs, and present possible mechanisms that may interact to influence and bias JOLs. In a second set of experiments (Chapter 3), I consider the generalizability of paired-associate learning for foreign-language vocabulary to the medical domain. Results show better cued-recall performance for translations compared to medications, though JOLs are somewhat insensitive to learning. Lastly, research on everyday attention suggests that frequent interaction with objects often does not benefit memory or metamemory for them. Across three experiments in Chapter 4, participants gave confidence judgments and completed eight-alternative forced-choice tests of the US, Canadian, and Mexican flags. In Experiment 1, environmental availability was correlated with confidence for the US flag, despite similar recognition performance at a saturated time point in the US (July 4th) and a neutral time point (Aug. 6th). In Experiment 2 and Experiment 3 I assess two techniques for improving both memory and metamemory for these types of materials. Via a draw-study paradigm, I introduce disfluency to improve performance, demonstrating a powerful metacognitive debiasing intervention and extending theories of errorful learning by highlighting the role of attention.

Want a new way to watch your favorites shows and movies?This book will help you discover everything there is to know about KODI.Step by step with pictures for every part of the process to help you along with installation and more. Here are a few of the things you will learn: -Installing Kodi on Different Devices -Background on Kodi-An Introduction to Hardware Compatible with Kodi -Troubleshooting Common Problems -How to Use Kodi (Tips and Tricks) -Is Kodi Legal or Not?

From Tin Pan Alley to the Beatles to Beyoncé, "Mr. Bradley skillfully breaks down a century of standards and pop songs into their elements to reveal the interaction of craft and art in composition and performance." (The Wall Street Journal) Encompassing a century of recorded music, this pathbreaking book reveals the poetic artistry of popular songs. Pop songs are music first. They also comprise the most widely disseminated poetic expression of our time. Adam Bradley traces the song lyric across musical genres from early twentieth-century Delta blues to mid-century rock ''n'' roll to today''s hits. George and Ira Gershwin''s "Fascinating Rhythm." The Rolling Stones'' "(I Can''t Get No) Satisfaction." Rihanna''s "Diamonds." These songs are united in their exacting attention to the craft of language and sound. Bradley shows that pop music is a poetry that must be heard more than read, uncovering the rhythms, rhymes, and metaphors expressed in the singing voice. At once a work of musical interpretation, cultural analysis, literary criticism, and personal storytelling, this book illustrates how words and music come together to produce compelling poetry, often where we least expect it.

Collected together for the first time, the best weird fiction from Morpheus Tales, the UK''s most controversial weird fiction magazine! Only the very best weird fiction has been hand-picked from the Morpheus Tales archives to create the sixth collected volume of the magazine Christopher Fowler calls "edgy and dark". Featuring fiction by Richard Wolkomir, Stuart Hughes, Ty Schwamberger, Paul Johnson-Jovanovic, Matthew Acheson, K. Scott Forman, Charles D. Romans, Craig Saunders, Matt Leyshon, Michael Lejeune, Michelle Ann King, Bruce L. Priddy, Douglas J. Ogurek, Harley Carnell, Stephen McQuiggan, Joe Mynhardt, David McGuire, Richard Farren Barber, Lee Clark Zumpe, Todd Outcalt, Kevin G. Bufton, Charles Austin Muir, Michael W. Clark, Anthony Baynton, Stephen Hernandez, Holly Day, Craig W. Steele, A.A. Garrison, David Barber, John S. Barker, David Buchan. Established horror best-sellers rub shoulders with rising stars and newcomers in this diverse collection of short weird fiction.

Collected together for the first time, the best weird fiction from Morpheus Tales, the UK''s most controversial weird fiction magazine! Only the very best weird fiction has been hand-picked from the Morpheus Tales archives to create the fifth collected volume of the magazine Christopher Fowler calls "edgy and dark". Featuring fiction by David Lear, Brockton McKinney, Lee Clark Zumpe, Robert Sagirs, Sean Logan, Adrian Ludens, Candra Hope, Ed Plotts, Glen Garrick, Matthew Piskun, Deborah Walker, Paul Johnson-Jovanovic & James Brooks Anthony Baynton, Sharon Baillie, Matt Leyshon, Matthew Acheson, Kyle Hemmings, James Gabriel, Gary Budgen. Established horror best-sellers rub shoulders with rising stars and newcomers in this diverse collection of short weird fiction.

When it comes to the arts and sciences, Northrop Frye argues that “it is clear that the arts do not stabilize the subject in the same way that science does. . . The stabilizing subject of science is usually identified with the reason; the unstabilizing subject is normally called the imagination”. Since the nineteen eighties, with the institutionalization of Humanities Computing research, there have been attempts at combining humanistic questions with technological innovations, and by extension, scientific concerns. Within the digital humanities there is a tension between these two positions that often results in the neglect of the human analyst and an elevated use of technology when applied to tool design. This can be seen in the current trend of distant reading, which is the batch processing and analysis of text corpora using machines. This approach stands in stark contrast to close reading which traditionally in English studies has entailed looking at individual words and their relation to a text as a whole in terms of not what the text means, but how it means. In this thesis I argue that the bridge between technology and literary criticism can be built using digital tools as long as those tools allow access to both the reason of science and the imagination of art. I present four digital projects that each investigate this problem in a novel way: (1) I use an algorithmic approach to investigate T.S. Eliot''s own theoretical position in terms of his diction, (2) I designed and developed a visualization of the English language, LDNA, that can be recovered back into the original text, (3) I conducted a study with 14 expert literary critics to analyze their current methods and used these results to design a tool, MetaTation, that can be integrated into the literary critical process, and (4) I also demonstrated how evidence-based testing of literary theory can be done in the context of Engineering writing by conducting a study that tests the feminist theory of false universals in human-computer interaction literature. I use these projects to present a hybrid approach that answers the question: How do we reconcile the specificity and human dependent nature of an unstable and imaginative close reading with the historic breadth and reason of a distant reading approach?.

For the first time collected together, the best weird fiction from Morpheus Tales, the UK''s most controversial weird fiction magazine! Only the very best weird fiction has been hand-picked from the Morpheus Tales archives to create the fourth collected volume of the magazine Christopher Fowler calls "edgy and dark." Featuring fiction by Gary Budgen, Alex Davis, James Everington, R. K. Gemienhardt, Dean M. Drinkel, Michael W. Garza, John S. Barker, Brick Marlin, Kurt Fawver, John F. D. Taff, Charles A. Muir, Martin Slag, Lenora Farrington-Sarrouf, Deborah Walker, Cate Caldwell, Richard Smith, Alex Gonzalez, Erik T. Johnson, Brian Kutco, Heather Smith, John Morgan. Established horror best-sellers rub shoulders with rising stars and newcomers in this diverse collection of short weird fiction.

For the first time collected together, the best weird fiction from Morpheus Tales, the UK''s most controversial weird fiction magazine! Only the very best weird fiction has been hand-picked from the Morpheus Tales archives to create the third collected volume of the magazine Christopher Fowler calls "edgy and dark". Featuring fiction by Simon Addams, Barbra Annino, Richard Farren Barber, David Brookes, Eric S. Brown, Kevin Brown, Tom Cardamone, Lee Collins, Nicholas Day, Thomas Henry Dylan, Paul Eckert, Craig Hallam, Andrew Hook, Adrian Ludens, David McGillveray, Christian McPhate, Colin Meldrum, Andrew Morris, Aaron Polson, John M. Radosta, Willie Smith, Alan Spencer, Wayne Summers, Lennart Svensson, Kevin Wallis. Established horror best-sellers rub shoulders with rising stars and newcomers in this diverse collection of short weird fiction.

For stay-at-home parents, exchanging adventures in the business world for those at home can be full of surprises. Bradley tells of his own transition to a stay-at-home dad to discover the art of listening to his child and learning how to become the man his daughter needs. The Adventures of a Stay-At-Home-Dad is a collection of seven short stories recounting the shift in perspective Bradley discovered on God, himself, and the world around him. Each story concludes with an opportunity for the reader to self-reflect on his or her own journey. This book is perfect for individuals or small groups to journey through together.

From the hip hop icon and Hollywood star, a candid, "New York Times"-bestselling memoir ranging from his childhood on Chicago''s South side and his emergence as one of rap''s biggest names.

For the first time collected together, the best weird fiction from Morpheus Tales, the UK''s most controversial weird fiction magazine! Only the very best weird fiction has been hand-picked from the Morpheus Tales archives to create the second collected volume of the magazine Christopher Fowler calls "edgy and dark". Featuring fiction by K.C. Ball, Skadi medic Beorh, L. R. Bonehill, Tonia Brown, Jesse Click, Tim Eagle, Chris Ewing, Ray Garton, Lee Gimenez, Gail Gray, K.J. Hannah Greenberg, Ian Hunter, Gary Inbinder, Dev Jarrett, Mark Howard Jones, Paul Johnson-Jovanovic, Fred R. Kane, Brian Kutco, Joe R. Lansdale, David Lear, B. Miller, Louise Morgan, Lee Pletzers, Hunter Shea, Fred Venturini, Nathan Wellman, C.E. Zacherl, and A. David Zapata. Established horror best-sellers rub shoulders with rising stars and newcomers in this diverse collection of short weird fiction.

For the first time collected together in one volume, the best weird fiction from Morpheus Tales, the UK''s most controversial weird fiction magazine! Only the very best weird fiction has been hand-picked from the Morpheus Tales archives to create this first collected volume of the magazine Christopher Fowler calls "edgy and dark". Featuring fiction by Lyn Cannaday, Robert T. Canipe, Steven Lee Climer, Nickolas Cook, Garon Cockrell, Nick Day, Vic Fortezza, Ken Goldman, Gary Hewitt, Todd Austin Hunt, Michael Laimo, Kevin Lucia, Adrian Ludens, Christian McPhate, Mari Mitchell, Theresa C. Newbill, Aaron A. Polson, Jonathan J. Schlosser, Tommy B. Smith, Alan Spencer, Wayne Summers, Randy Young, Mark Zirbel, Lee Clark Zumpe. Established horror best-sellers rub shoulders with rising stars and newcomers in this diverse collection of short weird fiction.

Morpheus Tales, the UK''s most controversial horror, sf and fantasy magazine, proudly presents its first original dark fiction anthology: 13. Original fiction by Eric S Brown, Joseph D''Lacey, Gary Fry, Andrew Hook, Shaun Jeffrey, Matt Leyshon, Gary McMahon, Andy Remic, Stanley Riiks, Tommy B. Smith, Alan Spencer, Fred Venturini, and William R.D. Wood. Featuring a wide range of dark fiction, including horror, dark fantasy and dark SF, Morpheus Tales has pulled stories from around the world. 13 authors each present their own story: disturbing malevolence, personal fear, ghostly debts, the apocalypse, musical madness, sasquatch and more... All manner of disturbingly dark tales are contained in this collection. 13 tales of dark fiction.

Ralph Ellison may be the preeminent African-American author of the twentieth century, though he published only one novel, 1952’s Invisible Man. He enjoyed a highly successful career in American letters, publishing two collections of essays, teaching at several colleges and universities, and writing dozens of pieces for newspapers and magazines, yet Ellison never published the second novel he had been composing for more than forty years. A 1967 fire that destroyed some of his work accounts for only a small part of the novel’s fate; the rest is revealed in the thousands of pages he left behind after his death in 1994, many of them collected for the first time in the recently published Three Days Before the Shooting . . . . Ralph Ellison in Progress is the first book to survey the expansive geography of Ellison’s unfinished novel while re-imaging the more familiar, but often misunderstood, territory of Invisible Man. It works from the premise that understanding Ellison’s process of composition imparts important truths not only about the author himself but about race, writing, and American identity. Drawing on thousands of pages of Ellison’s journals, typescripts, computer drafts, and handwritten notes, many never before studied, Adam Bradley argues for a shift in scholarly emphasis that moves a greater share of the weight of Ellison’s literary legacy to the last forty years of his life and to the novel he left forever in progress.

The design, synthesis, characterization and application of carbene-based metallopolymers are described herein. Metallopolymers have found wide applications in the fields of photovoltaics, energy storage and electrochromic windows. The incorporation of N-heterocyclic carbene (NHC) functionalities into a polymerizable scaffold would allow for many different metals to be attached in a facile and high-yielding manner. Such complexes could be functionalized onto surfaces and utilized as either spectroscopic or antimicrobial devices. Early attempts in our lab focused on utilizing bis(thiophene) diimines (instead of NHCs) as scaffolds for metal chelation and polymerization. This approach was unsuccessful due to the lability of the diimine moiety under electrochemical cycling and the thiophene moieties were not able to undergo polymerization. In order to more fully understand the key transformation in synthesizing the thiophene-substituted diimines, a comprehensive investigation of the aldimine coupling transformation was undertaken. A high concentration of substrate and catalyst was determined to be the most important factor in obtaining high yields of the dimerized products. Green solvents such as acetonitrile and hexanes could be used for the dimerization reaction when the cyanide counteranion was changed from sodium to tetrabutylammonium. The steric limitations were systematically identified and a series of possible substrates have been ruled out as viable candidates for dimerization. Applying the experience gleaned from earlier reports, the first example of an NHC polymer was prepared in which the monomer features an NHC functional group orthogonally connected to its main chain. A polymerizable imidazolylidene-AuCl complex containing pendant bithiophene moieties was prepared by a high yielding, multistep procedure. Oxidative electropolymerization of this monomer afforded the desired polymer (Au[NHC]Cl)n, which was characterized on the basis of electrochemical studies as well as by X-ray crystallography, photoelectron and UV-vis spectroscopy. The methodology described above was expanded to develop a series of analogous poly(N-heterocyclic carbene) complexes with appended entities (M = Ir, Au, Ag, or S)and found to be electrochromic. Most of the polymers exhibit an intense absorbance wave at 700 nm under oxidative conditions which is attributable to the formation of polaron excitations along the polymer main chain. The presence of a transition metal significantly increased the electrochromic character of the polycarbene system. The iridium-containing polymer was found to possess significant near-infrared (NIR) absorbance at 1100 nm in which the metal moiety effectively functions as an electron sink. Electrochemical analysis of the polymer thin films revealed that they exhibit highly reversible electrochromic activities.

One of hip-hop studies'' brightest young scholars celebrates the lyrics of hip hop as the most vivid, most revolutionary form of American poetry today.

Threshold is a fundamental concept in architecture, denoting inside, outside, and the transition between. It therefore implies movement. The concept of threshold is used in this work to develop a mental health recovery center - a place of healing and reactivation. The spectrum of mental health states one experiences throughout the healing process is acknowledged and considered holistically. The movement between states is studied in parallel with spatial issues of threshold: pause, movement, transition, and encounter. The proposed architecture is generated through an understanding of dynamic psychological and emotional conditions. I propose this empathetic approach to architecture and, in particular, to the design of a healing environment in tandem with a reconsideration of contemporary mental health treatment; threshold is central to both. The document provides background information about mental health, various attempts at innovation, systems of care giving, and the site of the proposed interventions. The architectural design is described in detail based upon the aforementioned concept of threshold.