Most Popular Books by Robert Cook

Second, we hypothesize that FoxO1, a key insulin-inhibited transcription factor, coordinately regulates both hepatic glucose and lipid homeostasis. We have developed a transgenic mouse model heterozygous for a knocked-in allele of DNA binding-deficient FoxO1 and have proceeded to dissect the mechanisms by which FoxO1 differentially regulates glucose and lipid handling. We found that while the former requires FoxO1 to bind to its consensus sequences in target-gene promoters, the latter proceeds via a co-regulatory action of FoxO1. Taken together, these findings reveal novel connections between the glucose and lipid "arms" of the insulin-signaling pathway and how they may go awry in the run-up to diabetes.

This research explores the views, beliefs and knowledges of experts responsible for flood management in Bangladesh. As one of the most disaster-prone nations on Earth, and in response to the neglect of power-holding experts within the existing literature, this project analyses the differences between academic accounts of flooding, labelled the?prevailing understanding?, and the local expertise of those responsible for management. Relative to the entrenched narrative, local experts are surveyed and an alternate interpretation is constructed using their knowledge. This combination of textual and perception-based analyses accounts for the complex interrelations between competing forms of knowing. It is on this juxtaposition that the research contributes to new knowledge. The thesis is based on research conducted in Bangladesh between November 2007 and March 2008. To accomplish its objectives, using prominent debates as entry points, academic and government sources are used to account for the lineage of the prevailing understanding. On the basis of this narrative, qualitative interviews with 54 experts explore the construction of flood management knowledge and its relationship with decision making. The experts describe and justify understandings of flood management that are contextual, adaptive and indefinite, challenging many of the assumptions associated with the prevailing understanding. The findings inform several findings: that individuals close to the poverty line are uniquely vulnerable; that disasters merge with management to produce second-generation events; and that a hybrid socio-physical context is both a product and a producer of flood management knowledge. Overall, despite the already complex issue of flooding, managers in Bangladesh consider increasingly issues as diverse as poverty, environmental sustainability and economic and human development. Given the scope of the controversy surrounding flood management, the findings show how analyses of competing knowledges, assumptions and framings can aid the interrogation of prevailing knowledge to generate original findings.

Through the eyes of little children and "talking" pets, Mr. Happy explores Happy World through the innocent eyes of children in brightly colorful pages.

This 24-lecture course is intended to help you analyze and appreciate the long poem by Dante Alighieri (1265-1321) known as the Divine Comedy.