New Releases by Michael Williams

The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black''s H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.

Almost every neurologist encounters ethical issues daily. This exemplary ethics text meets the needs of students, residents, fellows, and practicing neurologists who want an accessible case-based text for learning, and it meets the needs of directors of medical student clerkships and residency programs in neurology who want an accessible case-based text for teaching. The book’s case-based approach places key ethical principles into a practical, real-world context to aid in decision-making. Each chapter includes an outstanding array of learning features includes Learning Objectives, Clinical Vignettes, Questions to guide self-study and group discussions, Key Points, Key Words, Suggestions for Further Reading, and more. Clinical Pragmatism model helps readers analyze ethical issues in a clinical context. Practical Ethics in Clinical Neurology is a companion to the most highly respected ethics text in neurology and neurosurgery, Bernat''s Ethical Issues in Neurology, 3rd edition.

Starting with a young man losing consciousness and collapsing in a mall while walking toward his wife, a chain reaction is manifested. With each life that is affected, there is an elderly woman named Mae Nell Harris who is coincidentally placed in their lives to help them through her wisdom. With the unknowingly assistance from a man who seems to appear and vanish when tragedy strikes, the lives affected are challenged to trust a stranger when they don''t know what else to do. But whatever they choose, their lives about to change.

New York Times–bestselling series: Discover the backstory of Sturm Brightblade, the noble Solamnic Knight and future Hero of the Lance Although twins Raistlin and Caramon Majere urge him not to go, Sturm Brightblade attends an annual Solamnic ceremony that is interrupted by a stranger who offers a taunting challenge and clues from the past. He speaks of death . . . Once young Sturm accepts a mysterious gauntlet, he must undertake a dangerous journey with some curious friends, rescue a fair if querulous maid, defeat a traitor knight, and learn the secret fate of his long-lost father. And most important of all, he must learn the true meaning of honor.

The world’s most reluctant knight, Galen Pathwarden, returns for another misadventure in this exciting sequel to Weasel’s Luck Becoming a knight has changed the Weasel very little. Galen Pathwarden is still wary of seeking adventure—and still out to save his own skin at virtually any cost. But when his brother Brithelm vanishes mysteriously, Galen sets aside his better judgment and embarks on a quest that leads him under the earth, deep into a conspiracy of darkness, and to the very end of his courage. Once more, this reluctant knight returns to the imperiled nation of Solamnia, where he will learn if he has what it takes to be a true hero.

The world’s least promising knight gets his first taste of high-stakes adventure in this rollicking and fantastical Dragonlance tale Weasel''s luck was not always good . . . Galen Pathwarden, known as "the Weasel", would give anything to stay clear of adventure, danger, or heroism. Cowardly, deceitful, and hardly noble—and mired in a backwater castle far from any action—he bickers with his siblings and schemes against his elders. But one fateful night, Galen’s dreary life is turned upside down when a sinister visitor arrives bearing gold, unspeakable magic, and a centuries’ old curse. The encounter launches Galen on a bizarre quest into swamp and forest, headed toward a mythical fortress. With the great Solamnic Knight, Sir Bayard Brightblade, and a none-too-bright centaur named Agion at his side, Galen must overcome the schemes and traps of a sinister illusionist known only as the Scorpion.

... This book provides step-by-step instruction for implementing a narrative-based approach as an alternative to traditional discipline strategies.

The King James Old English Word Definition Guide,3rd edition, KJV 400th Anniversary Pocket Size, enables the user to read the most accurate English Bible ever translated from the historically reliable Masoretic Hebrew and Received Greek texts without struggling with the Old English words. Originally published in 2001 followed by a 2nd edition revision in 2008, this 400th Anniversary of the King James Bible 3rd edition substantially adds to the previous editions.This 3rd edition adds two hundred more Old English words for a new total of over eight hundred words. It adds a new section of King James helps, which explain some of the techniques the translators used to ensure important information in the original texts was clarified and communicated. Finally this edition is smaller in size so it fits better inside a Bible cover, pocket, or purse.

This book focuses on the academic foundations, trends and traditions of environmental education for sustainable development principally in Chinese contexts. It highlights contexts and case studies that illuminate recent Chinese initiatives. It includes case studies of green schools and reports on recent initiatives in school-based ESD curriculum development programmes in China, Hong Kong, Macao and Taiwan. The book concludes with an overview chapter that points to likely future developments. The assumption underpinning the book is that experiences gained in such a major country as China will be of real interest to geographical and environmental educationists, professional educators and teachers elsewhere. Not only will it generate interest and create greater awareness but also it is hoped that these experiences will provide a platform for scholarly exchange and contribute insights on education policy and curriculum changes across Asian-Pacific communities in an increasingly globalised world.

This book examines the role of culture in contemporary security policies, providing a critical overview of the ways in which culture has been theorized in security studies. Developing a theoretical framework that stresses the relationship between culture, power, security and strategy, the volume argues that cultural practices have been central to transformations in European and US security policy in the wake of the Cold War – including the evolution of NATO and the expansion of the EU. Michael C. Williams maintains that cultural practices continue to play powerful roles in international politics today, where they are essential to grasping the ascendance of neoconservatism in US foreign policy. Investigating the rise in popularity of culture and constructivism in security studies in relation to the structure and exercise of power in post-Cold War security relations, the book contends that this poses significant challenges for considering the connection between analytic and political practices, and the relationship between scholarship and power in the construction of security relations. Culture and Security will be of interest to students and researchers in the fields of international relations, security studies and European politics.

This book reveals the key skills needed by any leader in any type of business and shows how they can be used in practice, focusing on techniques for improving individual and organizational performance and enabling mid- to senior-level managers to understand their own leadership style. It provides guidance on how to develop a learning organization and how to be a successful mentor. It will be perfect for newly appointed managers looking for an expert but user-friendly introduction to this crucial role; departmental managers across the functions--i.e. finance, HR, production, marketing--who need to develop key skills outside their own area of expertise; in-company training courses; and business degree and MBA courses.

Profiles different models of tractor, from the early John Deere Model D tractor to the more modern Massey Ferguson 8480.

School improvement is at the centre of educational reform and is perceived by many as a key to social and economic advance. It contributes to determining the personal fulfilment and career paths of individual students and consequently engages the interest of parents and community members. It is an ever-present commitment of teachers and managers in schools. Policy makers and politicians at international, national and local levels devote much time and effort to their search for better schools. School improvement has also attracted the attention of researchers and scholars in many countries. They have been drawn from various disciplines and fields within the educational studies community, including psychology, sociology, history, evaluation, and studies in curriculum and assessment. There is now an established body of findings from studies conducted in many contexts. This book brings together leading experts drawn from many countries and several continents, reflecting diverse approaches to educational policy and practice, evaluation and research. Variations between countries and between local communities within countries are highlighted. The possibilities and difficulties inherent in transferring evidence from one educational system, at a number of levels, to another are clearly discussed. What emerges from the cross-national and cross-cultural evidence are several significant threads, currently under active investigation, including: school structure and management, classroom organisation, school leadership, teacher training and staff development, curriculum and assessment, community involvement, lifelong learning and special provision for students with special educational needs. "School Improvement: International Perspectives" is written for national educational policy makers, teachers and student teachers, governing bodies and parents from various levels of schooling, and university researchers and scholars.

An omnibus edition containing the three novels in the Legends series is accompanied by extensive notes by the authors, as well as commentary from the original members of the Dragonlance setting conceptual team.

Since humans first appeared on the earth, we''ve been cutting down trees for fuel and shelter. Indeed, the thinning, changing, and wholesale clearing of forests are among the most important ways humans have transformed the global environment. With the onset of industrialization and colonization the process has accelerated, as agriculture, metal smelting, trade, war, territorial expansion, and even cultural aversion to forests have all taken their toll. Michael Williams surveys ten thousand years of history to trace how, why, and when human-induced deforestation has shaped economies, societies, and landscapes around the world. Beginning with the return of the forests to Europe, North America, and the tropics after the Ice Ages, Williams traces the impact of human-set fires for gathering and hunting, land clearing for agriculture, and other activities from the Paleolithic through the classical world and the Middle Ages. He then continues the story from the 1500s to the early 1900s, focusing on forest clearing both within Europe and by European imperialists and industrialists abroad, in such places as the New World and India, China, Japan, and Latin America. Finally, he covers the present-day and alarming escalation of deforestation, with the ever-increasing human population placing a possibly unsupportable burden on the world''s forests. Accessible and nonsensationalist, Deforesting the Earth provides the historical and geographical background we need for a deeper understanding of deforestation''s tremendous impact on the environment and the people who inhabit it.

Fantasy roman.

This set of twelve previously unpublished essays on historical geography written by Darby in the 1960s explains the basis of his ideas. The essays are divided into three quartets of studies relating to England, France and the United States.

Soloman Hawken must use magic to save his family and maybe even the entire world from the pull of the mysterious Absences.

In Unnatural Doubts, Michael Williams constructs a masterly polemic against the very idea of epistemology, as traditionally conceived. Although philosophers have often found problems in efforts to study the nature and limits of human knowledge, Williams provides the first book that systematically argues against there being such a thing as knowledge of the external world. He maintains that knowledge of the world consitutes a theoretically coherent kind of knowledge, whose possibility needs to be defended, only given a deeply problematic doctrine he calls "epistemological realism." The only alternative to epistemological realism is a thoroughgoing contextualism.

A rich novel about a young man from Soweto, whose life changes dramatically when he joins the cast of a musical that travels to Broadway.

Dr Williams begins by exploring the role of the forest in American culture: the symbols, themes, and concepts - for example, pioneer woodsman, lumberjack, wilderness - generated by contact with the vast land of trees. He considers the Indian use of the forest, describing the ways in which native tribes altered it, primarily through fire, to promote a subsistence economy.

Increasingly we understand that no ethnic community is monolithic but shows a great degree of diversity in demographics, class and socio-economic status. This volume demonstrates this in its focus on the black ageing community, showing how these diversities have enormous implications for social services, social programmes and social policy. In these twelve informative, incisive essays, the state of America''s black aged is assessed and policies and programmes analyzed. The authors point to the importance of gearing services to a diverse group of elderly people. They also highlight how traditional racism and economic limitations impact on service needs and uses. Finally, they note the importance of family, church and other informal support networks in the black community as a substitute for or supplement to more formally-delivered services. Written by some of the best known scholars and professionals in the field of gerontology, the essays in this book will be required reading for all those delivering services to minority aged clients.