Most Popular Books by Mary Williams

Biosynthesis and folding of proteins entering the secretory pathway of eukaryotic cells is coordinated at the endoplasmic reticulum (ER). Any terminally misfolded proteins are sorted for the endoplasmic reticulum associated degradation (ERAD) pathway for destruction. Eeyarestatin I (ESI) is a potent inhibitor of certain stages of protein biogenesis at the ER including protein translocation across the ER and deubiquitination, a late stage of the ERAD process. Here several structurally related Eeyarestatins (ES) were synthesised based on key structural requirements shown in ESI and the structural activity relationship of these compounds both in vivo and in vitro was investigated. Experiments conducted included: cytotoxicity to determine toxicity of ES compounds at several concentrations; cell microscopy to identify vacuole formation frequently exhibited by ESI; SDS page electrophoresis and western blotting for ubiquitin to ascertain the extent of accumulation of ubiquitinated protein and indicator of inhibition of deubiquitination; a translocation block assay looking to determine the inhibitory effect the ES compounds have on translocation of selected proteins across the ER membrane; and finally a secretion assay to determine the ES compound''s ability to block overall secretion of proteins from cells. Whilst none of the ''new'' analogues seem to be equipotent to ESI in all inhibitory activities, inhibitory activity of compounds ES40, ES24 Click meta and ES24 Click para appear to be more specific towards DUBs, with ES40 being the most active.

"This single case study uses a narrative approach to explore the personal and spiritual experience of a woman diagnosed with advanced breast cancer. Previous to this diagnosis, this woman had completed the Spiritual Exercises of Ignatius Loyola. The data for this study was collected by way of tape-recorded, in-depth, unstructured interviews which took place over a six-month period. It has been written up in the form of a personal narrative and analysed using significant elements from the Spiritual Exercises. This study establishes that the Spiritual Exercises have had a formative place in this woman''s life and have assisted in her quest for meaning."--Abstract, p. ix.

A lot of people suffer from acne. Acne can happen to anyone, any time. It shows up primarily in the face and can cause embarrassment and even avoidance of going out in public. Anyone with acne has one goal in mind: to get rid of it!Some people only experience light, occasional break-outs. Unfortunately for others, this problem can go on for years and requires treatment. There are several choices when it comes to healing yours. A dermatologist is recommended for severe or frequent blemishes. Natural Acne Treatment is the ideal remedy for milder cases. Do you want to achieve acne-free skin? Then, this book will be your comprehensive skin care guide in teaching you the most effective acne skin care treatment, the best acne skin care products and natural skin care tips that really works for all skin types so that you can absolutely get rid of acne forever.This book presents 65 mini-chapters about acne and how to effectively stop it. This book also highlights:* Understanding Acne And Its Devastating Results* What Causes Acne* Types Of Acne* Types Of Acne Treatment Solutions For Your Skin* Natural Acne Treatment* Medications For Acne* Acne Scar Removal* Tips For Getting An Acne-Free FaceDon''t let acne ruin your life! Beat acne with 65 superior truths enclosed in this book and achieve a totally acne-free skin!

This is a book about a little boy''s imagination and the love he had for dinosaurs. In his world of autism and make believe, all he needed to complete his dreams was something to form a tail, then his fantasy of being a dinosaur would be complete.

"A study has been completed on the effects of weathering and biological degradation on ignitable liquids from each of the ASTM E1618 designated classes. Fifty ignitable liquids in the Ignitable Liquids Reference Collection (ILRC) database were weathered by evaporation of 0, 0.25, 0.5. 0.75, 0.9 and 0.95 fractions of the original volume. The same liquids were biologically degraded on potting soil for 0, 7, 14, and 21 days. Each of the weathered and degraded samples was added as a new record in the ILRC database. The ILRC database was modified to link all associated records from weathering and degradation of the same ignitable liquid. The data from all of the samples was reviewed by the ILRC Committee and evaluated with regard to the potential impacts of weathering and biological degradation on the interpretation of fire debris data. A "Best Practices" statement was prepared by ILRC Committee and placed on the ILRC database website. The "Best Practices" statement will serve to inform forensic practice and policy in laboratories conducting fire debris analysis. The evaporation rates were also modeled as a function of the fraction weathered and found to follow first order kinetic profiles. The natural logarithm of the fitted rate constants were found to exhibit varying degrees of linearity as a function of retention index. The kinetic analysis constitutes a preliminary investigation that may provide direction for future attempts to implement a digital weathering algorithm that would aid fire debris analysts in predicting, a priori. the chromatographic profiles of weathered ignitable liquids."

In this collection of occult stories, the mysterious and hinterland bordering life and death provides territory for a diversity of ghostly characters and uncanny experiences. By the author of Creeping Fingers.

Contains selected statistical tables from three major sources of national data: the Bureau of Justice Statistics, the Federal Bureau of Investigation, and the National Center for Health Statistics. Also contains the results of a topical search on homicide in the National Criminal Justice Reference Service data base and selected other Bureau of Justice Statistics publications dealing with homicide.

Letter describes sheep station life in the Riverina, including the environment.