Best Selling Books by Laura Jones

Easy Sudoku for Knitters Sudoku is one of the most popular games. It is a fun activity and helps to stimulate your adult''s brain. Research says that keeping the mind engaged is a great way to stay sharp while ageing. Some studies have shown that sudoku might help people reduce their risk of Alzheimer''s disease, cognitive decline, or dementia as they get older. Sudoku also creates a sense of accomplishment. Features: 100 easy Sudoku puzzles One puzzle per page Instructions and answers included Paperback, matte cover finish Great gift ideas for knitters on any occasion. Order today!

And what if Jack the Ripper was actually Florence Maybrick, a woman having existed in 1888? Here is the life of Florence Chandler, from the age of eighteen when she meets James Maybrick, her future English husband, herself being an American. This story is a blend of psychology, of facts concerning the criminal who terrorized England and of an authentic biography. Combining biography and real events, could this novel be a key?

A lot of people love making playlists of music to go along with whatever they have planned, whether it''s a playlist for the car during a summer road trip, a list to blast through the house while getting ready for school in the mornings, etc. Like when you''re going to the gym, you need some upbeat songs or music that makes you feel all big and bad, you know? Playlists are usually a really weird mixture of styles, with several different singers or bands. They''re not just a bunch of the same kind of songs, because that would get old, especially on a long road trip. This book takes a closer look at a book of the Bible that''s just like that. The book of Psalms is different from most books of the Bible, because it''s not written like stories of historical events or like a letter to specific people. Instead, it''s a collection of songs and prayers, written by a lot of different people over the course of over 600 years, from around 1060 B.C. to around 440 B.C. There are 150 psalms, and they cover a wide range of different moods and topics, just like most playlists do. For each psalm discussed, Playlist takes a look at two things: what do the verses actually mean, and how should that affect the way we think and act. Download Playlist now, and turn up the volume on the songbook of the Bible!

The Cyber Ky & Tekkie Guy Manage the Risk of Being Online Activity Workbook complements the children''s book titled "Cyber Ky & Tekkie Guy Manage the Risk of Being Online" published in 2019 by author Laura A. Jones. The workbook is designed to take children through activities that teaches and reinforces principles of cybersecurity and technology in an effort to help keep them safe from risks that are inherent to using the internet. The book also helps children begin to think about positively impacting the future as it relates to working in the areas of cybersecurity and technology. Help teach your kids cyber responsibility with a creative twist using fun, relatable characters! So, meet your newest cyber and tech heroes; Kyra and Guy, aka Cyber Ky and Tekkie Guy! Come along with Cyber Ky & Tekkie Guy as they share relevant information to help keep your kids to stay safe online, learn real-world terms and definitions and begin thinking about their cyber and tech interests today for potential careers in the future. Let author Laura A. Jones, with Cyber Ky & Tekkie Guy, help reinforce important principles your children will need for this Digital Era.

"The Mystical Amulet" is an enchanting children''s story that follows Kai, a curious young boy living in a coastal fishing village. During one of his morning beach explorations, he discovers a fish washed up on the shore. After helping the stranded fish back to the sea, Kai discovers it''s actually a sea fairy named Lira who rewards his kindness with a mystical amulet. This mysterious gift grants him the ability to transform into different sea creatures at will. As Kai explores the underwater world with Lira, he discovers a darkened section of the coral reef that other sea creatures avoid. Using the amulet''s powers, he transforms into various marine animals-first a colorful mandarin fish, then a powerful whale shark, and finally a clever sea turtle-each form helping him address different challenges. Together with Lira, Kai helps rescue Inky, an octopus trapped by tangled kelp, and in doing so restores life and vibrancy to a damaged portion of the reef. This beautifully illustrated tale weaves together themes of environmental stewardship, friendship, and the rewards of helping others. Through Kai''s underwater adventures, young readers learn about marine life while experiencing the joy of problem-solving and the importance of taking action to help those in need. The story celebrates curiosity, courage, and the magic that can be found in everyday acts of kindness.

Alone with only her difficult father, Hester, finds life lonely. From the day she brings home Katherine to the isolated farm where they live, the blinding monotomy of life ceases. The two forge an odd, co-dependent relationship plagued by questionable sanity, dark secrets and tragedy.

"Activation of the transcription factor Stat3 has been reported in numerous human cancers and is often correlated with poor prognosis. In particular, Stat3 activation has been reported in 30-60% of human breast cancers. Indeed, Stat3 regulates numerous targets involved in the processes of proliferation, angiogenesis, migration/invasion and immune response, all of which are essential to cancer progression. Furthermore, Stat3 activity has been specifically linked to metastasis, immune suppression and resistance to therapy. However, the use of genetically engineered mouse models (GEMMs) to examine the role of Stat3 in these processes has been limited. Utilizing a novel inducible PyVmT-driven mouse model of mammary tumourigenesis, we have highlighted an essential role for Stat3 in immunosuppression during early stages of tumour progression. Indeed, Stat3 loss results in a robust anti-tumourigenic immune response against early hyperplasic lesions in this model, driven primarily, but not exclusively, by activated cytotoxic T lymphocytes (CTLs) and M1 macrophages. This immune response was successful in the complete and rapid elimination of these early lesions. Furthermore, this model allowed us to examine a proportion of Stat3 ablated tumours that were able to eventually circumvent this immune surveillance, but lacked the ability to further metastasize. Here we report a down regulated Stat3-dependent inflammatory gene signature in these non-metastatic tumours and a corresponding lack of infiltrating macrophages, essential to metastasis. This firmly supports a role for Stat3 in modulating the tumour immune microenvironment at various stages of tumour progression. Differences in the immune microenvironment, however, did not fully account for a Stat3 dependent decrease in metastasis. Thus, we further examined the cell intrinsic roles of Stat3 in promoting breast cancer cell metastasis. Here we have shown that Stat3 ablation in breast cancer cell lines results in increased focal adhesion formation and a dysregulation of focal adhesion dynamics. This was correlated with impaired cellular migration and metastasis. Together, this suggests that Stat3 works through various mechanism to promote tumour progression and metastasis, and is thus an interesting target for potential therapeutic intervention. Nevertheless, important consideration should be given to how these transgenic mice are modeling breast cancer and if phenotypes are reproducible across models. In this vein, we have generated two novel inducible mouse models of breast cancer, driven by the human version of HER2 as well as a potentially activating, naturally occurring, alternatively spliced isoform. These models will allow for the investigation into differences between the signaling of the two HER2 isoforms, whose relative importance to human cancer is debated. With these new additions to our tool box, we can further examine these reported roles of Stat3 in an increasingly robust manner, parse differences between models, and gain a better understanding of how these models represent the cancers we are attempting to study. In summary the work presented here strongly implicates Stat3 in promoting mammary tumourigenesis at various stages of tumour progression through both cell intrinsic and extrinsic processes with an emphasis on its role in modulating the immune system to the benefit of the cancer. However, it also stresses the importance of varied models to gain an improved understanding of these processes and potentially highlights context specific considerations related to Stat3-targeted therapies." --

Screenplay; "white pages."

Fluctuations in temperature greatly influence species'' distributions and ecological interactions. Climate change does not only challenge the physiological limits of species via changes in temperature regimes, but can also increase exposure to novel infectious diseases by restructuring community composition. These risks are amplified in agroecosystems, where many aspects of the landscape are heavily modified. Humans rely on the services provided by species in these agricultural landscapes, including insect pollinators, who may be vulnerable to the risks posed by climate change. The overarching goal of my dissertation is to assess the roles of climate and landscape composition on the thermal tolerance and pathogen transmission dynamics of bees in agroecosystems. I explore these relationships among pollinators that visit Cucurbita (e.g., squash and pumpkin) crops. In chapter 1, I hypothesized that species have greater cold tolerance at higher latitudes and elevations due to adaptation or phenotypic plasticity in response to temperature, and have higher heat tolerance at sites with local extreme temperatures and high relative humidity. I investigated the impacts of climate on the thermal tolerance of one species, the squash bee Eucera (Peponapis) pruinosa. Additionally, I assessed a suite of mitochondrial genes for polymorphisms given the known association between mitochondrial sequence variation and differences in cold acclimation. This species recently expanded its geographic range northward from Mexico and the southwestern United States to the province of Québec over the past ~2-3 kya, tracking the human cultivation of its host plants in the genus Cucurbita. I compared the thermal limits between populations in the xeric region of their ancestral range and in two temperate regions within their recently expanded range. I did not find evidence of adaptation in mitochondrial genes, but I found that the lower thermal limit (ranging from -6.4 °C to 10.4 °C) of E. pruinosa correlated with latitude and was strongly predicted by annual mean temperature. Thus, adaptation or plasticity in cold tolerance may have enabled the rapid northward range expansion of E. pruinosa across North America. In contrast, E. pruinosa heat tolerance was variable across populations, and the effects of temperature and relative humidity were sex-specific. Overall, the average upper thermal limit of E. pruinosa in this study (53.1°C ± 3.7 °C) provides an ample thermal safety margin compared to the highest temperatures recorded within the sampled range. In chapter 2, I hypothesized that populations persisting in warmer environments would have higher heat tolerance, however smaller body size or pathogen infection may reduce heat tolerance. I investigated the roles of body mass, microclimate, and pathogen infection on heat tolerance and its population-level variance among E. pruinosa in Pennsylvania (USA). I assessed how these relationships differed between sexes given the larger size and ground-nesting behavior of female E. pruinosa. I predicted that populations of E. pruinosa are more heat tolerant at warmer sites, but that female heat tolerance is better predicted by soil texture than air temperature given their ground nesting behavior. Additionally, I predicted that parasite infection would reduce heat tolerance. I compared the upper thermal limit of male and female squash bees between 14 populations, characterized microclimate, and assessed pathogen infection by three common groups--trypanosomes, microsporidians, and bacteria. I found that heat tolerance increased with body mass, and males show twice the increase in heat tolerance per milligram body mass compared to females. I did not find evidence that microclimate predicted heat tolerance, but found that the population-level standard deviation in the upper thermal limit decreases by 0.72 °C with every 1 °C increase in maximum temperature. One parasite group that is associated with sublethal symptoms in bees, trypanosomes, was negatively associated with heat tolerance in females. This work demonstrates that heat tolerance is highly variable, and exemplifies the need to evaluate trade-offs between infection and thermal tolerance. In chapters 3 and 4, I investigated the roles of host diet breadth and pathogen host-use efficiency in pathogen transmission dynamics. To test the hypothesis that host diet specialization increases pathogen prevalence and intensity, I investigated pathogen sharing dynamics in a simple multi-host community composed of a diet specialist--the squash bee E. pruinosa--and two diet generalists--the western honey bee (Apis mellifera) and the common eastern bumble bee (Bombus impatiens). I quantified infection levels of viruses, bacteria, and eukaryotic pathogens to determine if they are able to replicate within the host they are found in or are instead passively picked up. I found that most pathogens are detected in bee hosts but do not show high titer levels, particularly viruses, suggesting low susceptibility. In contrast with previous work in pollinator communities, my investigations have revealed that landscape has a small effect on pathogen dynamics in multi-host communities. I found that the most abundant host species in this system is the diet specialist, E. pruinosa, and that this species drives the prevalence and intensity of pathogens detected across communities. This work provides critical insight into the roles of landscape and the ecology of hosts and pathogens on the pathogen transmission dynamics among bees in agroecosystems. In summary, my work has revealed that host-pathogen dynamics and the impacts of climate on bee thermal limits are highly context-dependent. I found that bee heat tolerance is highly variable and poorly explained by climate data, which suggests that heat stress may be hard to detect or predict for solitary bees. In addition, pathogen sharing dynamics were largely driven by the diet specialists who held the highest pathogen titers, which may indicate that these native bees are more vulnerable to frequent and intense infections. This work exemplifies the need to evaluate climate impacts on both bee and pathogen fitness to predict pathogen pressure in bee communities under future climate scenarios.

This book is about one business owner''s experiences over the years from cleaning homes to running her own Home Cleaning business. It contains interesting stories about real life situations that employers face with employees and clients.From dealing with adversity with employees, to learning as much from the "bad" customers as from the "good" customers. The last chapter details best practices for cleaning that you may find useful in your personal or business life.

And what if Jack the Ripper was actually Florence Maybrick, a woman having existed in 1888? Combining biography and real events, could this novel be a key?A theory on the identity of Jack the Ripper, having as a central idea that the murderer was none other than a woman.Here is the life of Florence Chandler, from the age of eighteen when she meets James Maybrick, her future English husband, herself being an American.How was this ''foreigner'' driven in a corner? An insecure childhood, a castrating mother of easy virtue, an unfaithful husband and the puritanical Victorian era are all elements leading us towards the answer. This story is a blend of psychology, of facts concerning the criminal who terrorized England and of an authentic biography."

The aim of this research was to investigate the barriers to effective type two diabetes self-management faced by people in rural and remote areas of Australia. This research is timely for several reasons including the current rise in the prevalence of type two diabetes across the world (International Diabetes Federation [IDFJ, 2009), and data supporting the fact that that type two diabetes is poorly managed, especially in rural and remote contexts (Australian Institute of Health and Welfare [AIHW]. 2008a). Specifically, the research presented in this thesis aimed to identify barriers to effective self-management in rural and remote areas, to develop a tool for the measurement of these barriers, and to determine the importance of barriers to self-management in diabetes-dependant quality of life in both rural and urban populations. A mixed methods framework was adopted to address the aims of this research. This approach involved two separate but related data collections and three separate data analyses. Study 1 utilised the methods proposed by Braun and Clarke (2006) in order to conduct a thematic analysis regarding barriers to self -management. Semi-structured interviews with health professionals (n=18) and people with type two diabetes (n=10), and one focus group with people with type two diabetes (n=8) provided the data for this thematic analysis. A socio-ecological framework was used to organise identified themes. Results of Study 1 were subsequently used to inform the development of a survey for collecting quantitative data, which were used in Study 2 and Study 3. Study 2 used Principal Components Analysis to validate an adapted measure of barriers to effective type two diabetes self-management in a mixed rural and urban population (n=326). Study 3 utilised univariate and multivariate analyses to investigate both the demographic predictors of barriers to self-management, and the barrier predictors of diabetes-dependant quality of life in rural and urban populations. Study 1 identified barriers to effective self-management at intrapersonal, interpersonal, organisational and societal levels of influence. Across all levels of influence, the difficulty of maintaining lifestyle changes was emphasised. Results of Study 2 indicated that the adapted survey was valid in a mixed rural and urban population. Age, number of complications and remoteness were identified as significant predictors of various barriers to self-management in Study 3. Diabetes-dependant quality of life was similar in the rural and urban populations. Psychosocial barriers to management were the only significant predictor of diabetes-dependant quality of life in the rural population, while depression, psychosocial barriers and self-monitoring barriers were significant predictors of diabetes-dependant quality of life in the urban population. The research presented in this thesis identified barriers to effective type two diabetes self-management in rural and remote areas of Australia, and indicates that, of the barriers identified, psychosocial barriers are the most important in predicting diabetes-dependant quality of life in both rural and urban populations. These results have useful implications for provision of care in that they lend support to the principle that psychological and social factors must be taken into consideration if the goals of type two diabetes self-management, specifically improving quality of life, are to be realised across settings.