Best Selling Books by Jonathan Emmett

Meet Callum, a small boy with Big Ideas... and an Incredible Construction Kit with which to build them. Callum Loves to build. And when he is given the most incredible construction kit for his birthday, his imagination runs riot.

A fast-paced adventure, inspired by the traditional story of ''The Three Little Pigs'' in which the brave trio attempt to outwit the Big Bad Wolf for the second time. Each pig builds a plane - out of straw, sticks and metal.

Two fox cubs get more than they bargain for when they find they can''t resist playing with snowflakes, which they''d never seen before.

Pig is very proud of his neat appearance, so he''s horrified to discover a spot of squashed cherry on his side. But when his farmyard friends try to help - with disastrous results - the spot of bother soon becomes a truly calamitous catastrophe! Children will love following the exploits of Cow, Goat, Sheep and Pig in this hilarious pig-ture book romp. Brilliantly entertaining follow-up to the acclaimed The Pig''s Knickers ; "An entertaining and funny story with a joyous message about sharing your feelings with friends and learning that it is what is on the inside that counts." - The Bookseller on The Pig''s Knickers.

This book is part of TreeTops Fiction, a structured reading programme providing juniors with stories they will love to read. Offering chapter books with full-colour illustrations, written by well-known authors, these stories are full of humour and have real boy appeal. They are tightly levelled allowing children to read books appropriate to their ability. This book is also available as part of a mixed pack of 6 different books or a class pack of 36 books of the same Oxford Reading Tree stage. Each book pack comes with a free copy of up-to-date and invaluable teaching notes.

This book is part of TreeTops Fiction, a structured reading programme providing juniors with stories they will love to read. Offering chapter books with full-colour illustrations, written by well-known authors, these stories are full of humour and have real boy appeal. They are tightly levelled allowing children to read books appropriate to their ability. This book is also available as part of a mixed pack of 6 different books or a class pack of 36 books of the same Oxford Reading Tree stage. Each book pack comes with a free copy of up-to-date and invaluable teaching notes.

Fox finds a beautiful new coat, which, though too long, feels as if it were made for her. As she leaves the clothes shop, a loose thread catches in the doorway and by the time she arrives home her coat has completely disappeared.

Oxford Reading Tree All Stars are first class fiction at an appropriate interest level for Reception-Year 2/P1-P3. Their content is entirely suitable for able infant readers. The Teaching Notes included in the pack of six offer maximum support for every title and includes suggestions for guided reading, support for comprehension, support for writing and independent work and a photocopiable parent''s page for suggestions for reading at home. This class pack consists of 36 books. A mixed pack of six books is also available.

Endorsed for reading by Cambridge Assessment International Education, Cambridge Reading Adventures is our international primary reading scheme.

Divertido libro con pop-ups en el que el niño verá cómo se construye un edificios y descubrirá herramientas y vehículos que se utilizan para ello ampliando así su vocabulario.

Big voelt zich niet langer saai, hij heeft iets bijzonders: een rode onderbroek met witte stippen. Hij laat zijn nieuwe aanwinst trots aan de andere dieren zien. Prentenboek in oblong met paginagrote en kleinere kleurenillustraties. Vanaf ca. 4 jaar.

Mientras el cocinero duerme, un montón de animalitos hambrientos se han colado en la cocina.

Maulwurf möchte seine neue Freundin Maus vor Igel, Eichhörnchen und Hase geheim halten. Als sie ihn an seinem Bau antreffen lädt er sie nur zögernd ein. Plötzlich steht Maus vor der Tür. Sein Geheimnis wird gelüftet und Maulwurf erfährt, dass Teilen etwas Schönes ist. Ab 3.

Mol ziet voor het eerst de maan en wil deze proberen te pakken, maar dat lukt niet best. Prentenboek met grote schilderingen in nachtelijke tinten. Vanaf ca. 3 jaar.

Despite over three decades of active research, Human Immunodeficiency Virus Type I (HIV-1) represents a pressing and ongoing challenge to our ability to understand complex pathogens that threaten human health at global scale. This stems in part from the highly dynamic and multi-scale lifecycle of the virus, which is reflected in the necessity for multi-drug cocktails to suppress viral replication. A fundamental aspect of the HIV lifecycle is the insertion or integration across a plethora of sites in the human genome. From these sites of integration, the viral promoter coordinates multiple inputs from the cellular signaling environment, the local genetic and epigenetic context, and a virally encoded feedback circuit. Through integration of these inputs via a poorly understood transfer function, the viral promoter regulates the temporal probability of the expression of viral genes and ultimately the kinetics of the viral lifecycle. The HIV promoter, the long terminal repeat (LTR), is composed of a core TATA promoter and a large cis acting enhancer. Furthermore, two well-positioned nucleosomes form the basic epigenetic regulatory structures that regulate LTR output. These features are highly similar to endogenous mammalian promoters. Therefore, studies of the LTR can reveal insights relevant to HIV biology as well as mammalian gene control. HIV represents a highly attractive model system to apply large-scale experimental and computational analysis to systematically study the role of promoter architecture and genomic context in transcriptional regulation. Previous work demonstrated that the LTR operates in a stochastic regime, which results in large cell-to-cell differences in gene expression within clonal populations. In HIV model systems and natural circuits, it has been shown that such heterogeneity or noise can have dramatic phenotypic consequences. However, how such noise is related to the features of promoters, the local genomic context, and their interaction with genetic circuits and cell biology, is poorly understood. Here using combined large-scale experimental and computational analysis we develop systems to isolate and study the effects of viral integration positions, promoter cis acting architecture, transcriptional feedback and post-transcriptional processes on viral gene expression noise. Specifically, by using systematic experimental analysis of single integration clones coupled with computational modeling and statistical inference, we are able to link LTR gene expression noise to dynamic nucleosome occupancy. Furthermore, we develop a method to generate highly diverse combinatoric promoters that will enable systematic study of the LTR structure-function relationship. Additionally, we develop quantitative strategies to cluster highly heterogeneous feedback distributions and reveal characteristic moment scaling relationships. Lastly, using simulations and analysis of mRNA localization using RNA fluorescent in situ hybridization, we demonstrate that slow mRNA export can function as a low-pass filter to buffer the cytoplasm from the effects of noisy transcription. Together, these efforts reveal molecular and cellular processes underlying noisy gene expression. Furthermore, we develop novel systems level approaches and tools for the study of complexity in eukaryotic gene control.

Petite Taupe pense que son terrier est trop petit, trop sombre et sans intérêt. Elle se met donc en quête d''une BELLE maison, GRANDE et pleine de SOLEIL. Mais trouver la maison de ses rêves, ce n''est pas si facile !

Bradley Bartleby has been very bad since the day he was born and finally gets what he deserves after turning his family''s home into a fearsome trap for Santa, who has always given him nothing but socks.

De kleine vogel Rosie en de grote beer Robbie zijn zo verschillend als de zon en de regen, maar de beste vrienden. Door een misverstand krijgen ze ruzie en ontlopen ze elkaar. Maar dat houden ze niet lang vol. Prentenboek met kleurrijke, vertederende illustraties. Vanaf ca. 4 jaar.

In de gezellige winkelstraat vind je allerlei winkels, zoals een bakkerij en een feestwinkel, maar ook een restaurant. In de modewinkel koopt pinguïn Stig een nieuw pak en boven de wasserette doet kangoeroe Katinka een dutje. Hardkartonnen leporello, die kan worden uitgevouwen tot winkelstraat. Met vrolijk gekleurde illustraties en flapjes. Vanaf ca. 2 jaar.