Best Selling Books by Jen Wang

Poderosa y entrañable novela gráfica middle grade sobre la fuerza infinita de la amistad. Por la autora de El príncipe y la modista. Premio Eisner a Mejor Artista. Premio Eisner a Mejor Publicación para adolescentes. Premio Jóvenes lectores del Festival de Angouleme. Premio Mejor Cómic del año 2019 por la Asociación de Librerías de Madrid. Moon es todo lo que Christine no es: impulsiva, segura y creativa. A pesar de haber crecido en la misma comunidad chino-americana, no pueden ser más distintas, pero en cuanto Moon se muda al lado de su casa ambas se convierten en las mejores amigas, compartiendo su pasión por el K-Pop y pintándose las uñas cuando sus padres no miran. Un día, Moon le cuenta a Christine su secreto mejor guardado: en ocasiones tiene visiones, unos destellos en forma de ángeles que le susurran un mensaje desde las estrellas: la tierra no es realmente el lugar al que pertenece. Sin embargo, las visiones de Moon tienen un origen más terrenal de lo que cabría pensar, y de repente es ingresada en el hospital para una intervención quirúrgica de urgencia. ¿Podrá realmente ser Christine la amiga que Moon necesita ahora que todo se viene abajo? Jen Wang viaja a la infancia para crear una entrañable historia de amistad verdadera, una amistad que supera todas las dificultades imaginables y se convierte en pura emoción y esperanza. ENGLISH DESCRIPTION Stargazing is a heartwarming middle-grade graphic novel in the spirit of Real Friends and El Deafo, from New York Times bestselling author-illustrator Jen Wang. Moon is everything Christine isn''t. She’s confident, impulsive, artistic . . . and though they both grew up in the same Chinese-American suburb, Moon is somehow unlike anyone Christine has ever known. But after Moon moves in next door, these unlikely friends are soon best friends, sharing their favorite music videos and painting their toenails when Christine''s strict parents aren''t around. Moon even tells Christine her deepest secret: that she has visions, sometimes, of celestial beings who speak to her from the stars. Who reassure her that earth isn''t where she really belongs. Moon''s visions have an all-too-earthly root, however, and soon Christine''s best friend is in the hospital, fighting for her life. Can Christine be the friend Moon needs, now, when the sky is falling? Jen Wang draws on her childhood to paint a deeply personal yet wholly relatable friendship story that’s at turns joyful, heart-wrenching, and full of hope.

"Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among adults, age 60 and older, in developed countries. While oxidative stress is implicated in the pathogenesis of AMD, clinical studies have shown that dietary antioxidants can delay progression of AMD. Currently, there is no FDA-approved treatment for AMD. Therefore, we hypothesized that N-acetylcysteine amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD models. To achieve this, we used the oxidants tert-butyl hydroperoxide (TBHP) and sodium iodate (NaIO3) in a cell model and an animal model to evaluate the effects of NACA. Our data suggest that pretreatment with NACA reduces the sub-lethal (but not lethal) effects of TBHP in primary cultures of human retinal pigment epithelial cells. NACA significantly improves cell survival when administered prior to and during the occurrence of oxidative damage similar to that observed in the development of dry AMD. In the chemically- induced retinal degeneration animal model, NACA eye drops partially prevented reduction in visual function, as determined from electroretinograms (ERG) recorded 36 hours after NaIO3 injection. Other toxic effects were observed at a later time point after NaIO3 injection: increased lipid peroxidation (as measured by formation of 4-hydroxynonenal, 4-HNE), elevated cysteine levels, and death of photoreceptors resulting in outer nuclear layer thinning. NACA eye drops reversed these toxic effects. In conclusion, this potent antioxidant should continue to be investigated as a treatment for AMD"--Abstract, page iv.

Optically transparent, wide bandgap metal oxide semiconductors are a promising candidate for large-area electronics technologies that require lightweight, temperature-sensitive flexible substrates. Because these thin films retain relatively high carrier mobilities even in an amorphous state, metal oxide-based field effect transistors (FETs) can be processed at near-room temperatures. Compared to amorphous silicon FETs, which are the dominant technology used in display backplanes, metal oxide FETs have been demonstrated with higher charge carrier mobilities, higher current densities, and faster response performance. In this thesis we present a low-temperature (''1000C), scalable, fully lithographic process for top-gate, bottom-contact amorphous zinc indium oxide FETs using parylene, a room-temperature-deposited CVD polymer, as gate dielectric. Electrical characteristics were compared for FETs of varying device dimensions (W, L) using a standard set of extracted device parameters. We show in both simulation and experiment that the FET threshold voltage can be modified by varying the channel thickness alone, without requiring the additional complexity of multiple channel materials or different dopings. The baseline lithographic process was further developed to enable the integration of FETs of different channel thicknesses, and hence threshold voltages, on a single substrate. The availability of FETs with different threshold voltages allows the implementation of enhancement-depletion (E/D) logic circuits that have faster speeds and smaller device areas than single-VT topologies. Using the two-VT lithographic process, we fabricated integrated E/D inverters that operate at VDD as low as 3V with gains u003e 20 and symmetric noise margins ~1.2V. Furthermore, we demonstrated integrated 11-stage and 21-stage E/D ring oscillators that operated rail-to-rail at VDD= 3V and maintained oscillation for VDD as low as 1.7V. These results demonstrate the potential for low VDD metal oxide-based integrated circuits fabricated in a low temperature budget, fully lithographic process for large-area transparent electronics.

The Potential Role of Neuroendocrine in Patients with Attention-Deficit/Hyperactivity Disorder.

Improvement of manufacturing productivity is dependent on the successful automation of manufacturing processes, the success of which is based in turn upon the availability of information which describes the state of manufacturing operations. Acoustic Emission (AE) signals related to the cutting process and tool wear have been recently applied to monitor manufacturing processes, and various AE parameters can be used to provide process information. For example, when cutting tools become worn, AE energy generated at the interface of tool flank and work piece increases. This study is thus an experimental investigation of the AE spectrums representing AE signals energy distribution to determine the possibility of extracting useful parameters to provide on-line information about drilled-hole quality and drill-bit wear. An experiment conducted using a radial-arm drilling machine was employed to collect on-line AE drilling process spectrums, yielding eight indicator parameters. Drill wear states were measured using a machine vision system. Assessment of the drilled hole quality was based on tolerances established in Geometric Dimensioning and Tolerancing (GD & T). Correlations among drill wear, drilled-hole quality measurements, and the AE spectrum indicator parameters were examined by regression analysis. A forward-stepwise variable selection procedure was used to select the best-fit regression model for each drilled hole quality measurement associated with the set of one AE parameter raised to different powers. According to quality measurements, drilled holes were categorized as either "acceptable" or "unacceptable" holes, using cluster analysis with a group-averaging method. The usage of AE parameters to decide to which group a drilled hole belonged was also examined. From the experimental evidence, it was observed that there are strong relationships between AE parameters and drill-wear state and the quality measurements of drilled holes. AE parameters could be useful predictor variables to provide information to controller/operators to evaluate current drilling processes. Based on the status information of drill wear and the quality measurements, drilling processes can be adjusted accordingly.