New Releases by Heather Collins

Written for groups or individuals who want to collaborate to build learning objects, this book will also be useful to anyone with a desire to learn more about resource sharing, instructional design, and library instruction.

"The inactivation of the tumor suppressor Retinoblastoma (pRB) is a common tumorigenic event that helps cancer cells evade growth suppression. rbf1 is the functional homologue of pRB in Drosophila and rbf1 mutant eye imaginal discs exhibit cell cycle deregulation as well as a sensitivity to both cell death and differentiation defects. A Polycomb group protein, Posterior sex combs (Psc), was identified in a genetic screen designed to find factors that can specifically induce morphological defects in rbf1 mutant eyes. rbf1 mutations enhanced developmental phenotypes caused by Psc overexpression such as ectopic cell death and disorganized ommatidia. Our genetic analysis revealed that Psc-induced developmental defects were strongly influenced by Caf1p55, a shared component of chromatin-associated complexes including a histone chaperone dCAF-1. The expression levels of dCAF-1 components, CAF1p105 and CAF1p180, increased in rbf1 mutants. The upregulation of dCAF-1 was required for both the hypersensitivity of rbf1 mutant cells to Psc-induced cell death and for the cell death normally observed in rbf1 mutant eye discs. We propose that Caf1p105 and Caf1p180 are important determinants of cell death sensitivity in rbf1 mutant cells and contribute to the genetic interaction between Psc and rbf1.dCAF-1 also played a role in cell death sensitivity in other contexts such as wing discs and pupal eye discs. Reducing dCAF-1 components in eye imaginal discs increased EGFR activity offering a potential mechanism for the role of dCAF-1 in cell death. We postulated that other rbf1 mutant properties could be attributed to dCAF-1 upregulation. First, we demonstrated that the Notch pathway is ectopically activated when rbf1 is mutated and that rbf1 mutant eye discs are sensitive to Notch-induced photoreceptor dedifferentiation. Indeed, dCAF-1 was partly responsible for the rbf1 sensitivity to ectopic Notch. RNA-sequencing on eye discs expressing Caf1p180 RNAi was used to identify dCAF-1-regulated genes with the goal of uncovering the transcriptional targets responsible for the connection between EGFR, Notch and dCAF-1. This approach was unsuccessful in identifying candidate genes in these pathways but uncovered a novel set of genes that is regulated by both dCAF-1 and the E2F repressive complex dREAM. This set of commonly-regulated genes included germline-enriched genes that are not normally expressed in eye discs and have been shown to impact tumorigenesis. The significance of these genes in rbf1 mutant cells, where dCAF-1 is upregulated, remains unknown.Due to the pleiotropic nature of PSC overexpression, it was difficult to elucidate why rbf1 mutant cells are sensitized to PSC overexpression. To address this, we investigated the PSC domains required for PSC-induced phenotypes. Both complex formation and chromatin compaction are required to fully reproduce PSC-induced phenotypes such as loss of Sens, cell death and rough adult eyes. A C-terminal truncation, PSCdelta574-1603, and the homologous region alone, PSC233-552, acted as dominant negative forms of PSC causing hyperproliferation of the eye discs, derepression of a Hox gene Abd-B, and large, transparent larvae. Dominant negative PSC transgenes caused a decrease in PC nuclear localization. Surprisingly, these two dominant negative forms of PSC were not properly localized to the nucleus and were found predominantly in the cytoplasm. Some PSC233-552 entered the nucleus and colocalized with PC. PSC transgenes were examined for their ability to interact with rbf1 mutation. All of the transgenes genetically interacted with the loss of rbf1 to enhance the disorganization of photoreceptors albeit not to the same level as full-length PSC. In contrast, rbf1 mutation only increased the cell death phenotype when PSCdelta1-232 or PSCdeltaRING were expressed. The exact nature of the rbf1 mutant sensitization to PSC overexpression remains undetermined. " --

Four-week curriculum for young married couples focusing on spiritual growth within the marriage. Weeks include prayer and devotions, decision making, intimacy, and starting and raising a Christian family.

This text describes patterns that can be found in the environment that humans have made. Some of these patterns are meant as decoration, but other patterns are just there because of how an object is made.

Part of the Rainbow Reading range for Primary learners.

This text describes many of the patterns found in the natural environment.

When participants were asked where they go to get the most helpful support in solving their child's behavior problem, the majority of respondents reported that they go to the doctor, family, friends, and the Internet for support: Most found these avenues to be helpful in providing that support.

Go for an adventure with Koala, possum, emu and their friends as they fly, ride and glide their way through this delightful Australian wildlife picture book.

La nuit, par quoi est attiré ton regard ? Cherches-tu la Grande Ourse ou l'étoile Polaire ? Essaies-tu d'apercevoir une étoile filante ? Avec Mon Grand livre du ciel, découvre tous les secrets que recèle la nuit, invente des devinettes nocturnes, inscris tes expériences sur tin carnet d'astronomie, lis les mythes et les légendes su ciel que l'on raconte à travers le monde, et découvre le zodiaque, les aurores boréales, les éclipses et beaucoup d'autres choses. Et lorsque le ciel s'obscurcira, tu seras prêt pour le spectacle des étoiles !

Focuses on presenting the philosophical and ideological foundations of Adult Basic Education and Training in South Africa. The work examines South Africa''s shift from literacy to ABET and discusses the problems associated with each.

Ce livre offre un aperçu d'une cinquantaine d'espèces d'oiseaux du Canada. Il comprend des explications claires et des illustrations précises qui permettront à chacun d'apprendre à identifier les différents volatiles. Un ouvrage tout-indiqué pour qui désire se familiariser avec le monde fascinant des oiseaux.

Le Canada possède de nombreuses plantes, de la minuscule fleur sauvage à la gigantesque fleur de tournesol. Découvrez les fleurs de la ville et les fleurs de la campagne grâce aux informations et aux activités contenues dans ce livre!

Nursery rhymes are as old as time. Passed from one generation to another, these verses are still the best and the most entertaining way for young children to learn language. Heather Collins''s cheerful, animated illustrations tell the story in this favorite nursery rhyme. Just the right size for infants and toddlers, this sturdy board book with rounded corners is built to withstand a baby''s curiosity. It is sure to last --- and be loved --- well beyond the toddler years.

Este cuento que trata del VIH y del sida está dirigido a los niños de 4 a 8 años y a las personas que cuidan de ellos.