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Background/ObjectivesHPV Testing and Cytology are currently recognized in guidelines for cervical cancer screening in many countries. However, in many regions globally there are conditions that make it difficult to use these two methods to establish high-quality, high-coverage screening programs. Folate Receptor-mediated Detection (FRD u00ae) has been proposed as a reliable method to screen cervical intraepithelial neoplasia 2+ (CIN2, CIN3, and cervical cancer). This study aims to investigate the clinical significance of Folate Receptor-mediated Detection (FRD u00ae) by comparing the accuracy of Folate Receptor-mediated Detection (FRD u00ae) with that of HPV Testing and Thinprep Cytology (TCT).MethodsFrom January 2019 to March 2019, 81 patients in the gynecology clinic of the Second Hospital of Jilin University received screening with Folate Receptor-mediated Detection (FRD u00ae), TCT, and HPV examinations upon visiting the clinic. If any of the three tests provided a positive result, colposcopy was performed with biopsy being the gold standard for pathological diagnosis.ResultsThe sensitivity of Folate Receptor-mediated Detection (FRD u00ae), TCT, and HPV in the diagnosis of cervical intraepithelial neoplasia 2+ (CIN2, CIN3, Cervical Cancer) were 72.22%, 72.22%, and 83.33% respectively. The specificity of Folate Receptor-mediated Detection (FRD u00ae), TCT, and HPV in detection of CIN2+ (CIN2, CIN3, Cervical Cancer) was 65.07%, 60.31%, and 25.39% respectively. The accuracy of Folate Receptor-mediated Detection (FRD u00ae), TCT, and HPV in diagnosis of CIN2+ was 66.67%, 62.96% and 38.27%. The positive predictive value (PPV) of Folate Receptor-mediated Detection (FRD u00ae), TCT, and HPV in diagnosis of CIN2+ was 37.14%, 34.21% and 38.27% respectively, while the negative predictive value (NPV) was 89.13%, 88.37% and 84.21% respectively.ConclusionOverall, Folate Receptor-mediated Detection (FRD u00ae) provided high values of sensitivity, specificity and accuracy. While ensuring the detection rate, Folate Receptor-mediated Detection (FRD u00ae) has its own unique advantages in detection speed (results in less than 60 seconds), economic cost, and patient compliance (Screen and Treat). Folate Receptor-mediated Detection (FRD u00ae) can be a very beneficial and useful tool in the primary screening of cervical intraepithelial neoplasia 2+ (CIN2, CIN3, Cervical Cancer) especially in regions with hard to reach patients.

Features an interview with the three curators and a list of exhibited works.