New Releases by David Marquez

In the six months since the multipronged power struggle between Hydra, Leviathan, and Nick Fury blossomed into an all-out war on three fronts, each side has suffered extensive casualties. Trying anything he can to stop Hydra''s and Leviathan''s war on each other and the world, Fury, the battle-hardened leader of the Secret Warriors, finds as night falls and Seattle explodes that "anything" may mean some of the grittiest life-and-death choices his Warriors have ever seen him make.

While there have been many recently developed Elastic Network Models (ENM) to calculate the fluctuation dynamics of proteins, e.g., Gaussian Network Model (GNM), Anisotropic Network Model (ANM), Distance Network Model (DNM), the concept of loading these models to study the molecular mechanics and constitutive behavior of structural proteins has remained relatively untouched, until very recently. This work entails using the ANM as the framework for developing a finite element model of a 9-monomer strand of actin. Critical input parameters to the model, such as the cutoff radius, r[subscript c], and spring constant, k, are generated by matching the all-atom steered molecular dynamics (SMD) residue displacements to that of the ANM. The parameters yielding the best match between the SMD and structural ENM (SENM) simulations will then be input into the finite element model (FEM) for a more in depth analysis. The finite element model incorporates a 9-monomer strand of actin. The F-actin strand is subjected axial and torsional loads comparable to those seen in vivo. Key areas of interest in the protein are examined, such as the nucleotide binding pocket (NBP) and the DNase I binding loop, to demonstrate how loading affects the protein''s conformation. Local residue displacements are tracked in an effort to garner a better understanding of how various loads are transmitted through F-actin during key events. Insights and conclusions are discussed along with the implications of this work.

L''objectiu d''aquest llibre de problemes és omplir un buit dins el món editorial en el camp de les probabilitats. Els estudiants universitaris que cursen assignatures que tracten de probabilitats a un nivell elemental, poden trobar fàcilment un bon grapat de llibres per consultar, tant teòrics com pràctics. En canvi, quan una assignatura no té aquest caràcter tan bàsic, l''estudiant no disposa de cap llibre de problemes resolts. La publicació que teniu a les mans vol solucionar aquesta mancança. .El llibre conté 100 problemes resolts i 69 més de proposats amb unes indicacions de com resoldre’ls. A més, cada capítol inclou un petit resum teòric