New Releases by Charles Todd

“Stunning . . . the tragic sweep of Todd’s historical mysteries grows more expansive with each novel.”—The New York Times Book Review Called out into the teeth of a violent blizzard, Inspector Ian Rutledge faces one of the most savage murders he’s ever encountered. He might have expected such unspeakable carnage on the World War I battlefields where he’d lost much of his soul—and his sanity—but not in an otherwise peaceful farm kitchen in remote Urskdale. Someone has murdered the Elcott family without the least sign of struggle. But when the victims are tallied, the local police are in for another shock: One child is missing. Now the Inspector must race to save a young boy before he’s silenced by the merciless elements—or the even colder hands of the killer who hides in the blinding snow. Praise for A Cold Treachery “Todd’s Ian Rutledge mysteries are among the most intelligent and affecting being written these days.”—Washington Post Book World “Brilliant.”—Chicago Tribune “Traditional mystery lovers who prefer their whodunits enriched with psychological insight will heartily embrace A Cold Treachery. . . . A superb effort.”—Publishers Weekly (starred review) “Brilliantly conceived and elegantly executed.”—Strand magazine

“A stunner, exquisitely plotted and characterized, with Todd’s trademark meticulous backdrop of World War I-era England.”—Strand Magazine The Great War is still raging when Francesca Hatton’s adored grandfather dies on the family estate in England’s isolated Exe Valley. Among his effects, Francesca is stunned to find an unsigned letter cursing the Hattons and their descendants. Then a stranger appears, accusing her grandfather of murder. Was the loving protector Francesca remembers really a vindictive man who cultivated dangerous enemies? At the center of the intrigue is an unusual white stone hidden in a garden where Francesca once played with her five male cousins—all dead now on France’s battlefields. According to Hatton’s will, the Murder Stone must be dug up, transported to Scotland, and buried forever. But before Francesca can begin the journey, a series of ominous “accidents” occur. As Francesca sets out to pursue the truth, she also sets herself in the sights of someone determined to exact a revenge too long overdue. Praise for The Murder Stone “Todd’s mysteries are among the most intelligent and affecting being written these days.”—Washington Post Book World “Seamless . . . a compelling insight into the home front during 1916.”—Chicago Tribune “A gripping novel of family secrets set against the tragedy of World War I.”—Mystery Lovers Bookshop News “Many twists and turns, angst-ridden characters, and an evocative historical setting. A gripping read.”—Library Journal

“[Charles] Todd’s mysteries are among the most intelligent and affecting being written these days.”—The Washington Post Book World In 1912 Ian Rutledge helped gather the evidence that sent Ben Shaw to the gallows. Now, seven years later, Ben Shaw’s widow brings Rutledge evidence she’s convinced proves her husband’s innocence. Ben Shaw’s past is a tangle of unsettling secrets that may or may not be true. And it grows only more twisted when a seemingly unrelated murder brings Rutledge back to Kent. There an unexpected encounter revives his painful memories of war—and the voice of Hamish MacLeod, the soldier Rutledge was forced to execute. Two elusive killers are on the loose at the same time . . . and to catch them before they catch him, Rutledge will be forced to question everything he believes about right, wrong—and murder. Praise for A Fearsome Doubt “Brilliant . . . Who’d have thought that Charles Todd’s brilliant concept for a mystery . . . would not only continue but grow stronger from book to book.”—Chicago Tribune “Todd raises the stakes in this series to new and nearly unbearable levels.”—The New York Times Book Review “A brilliant and gripping whodunit . . . an outstanding historical mystery and literate period fiction.”—Publishers Weekly (starred review)

“If anyone can turn a simple village mystery into a brooding Greek tragedy, it’s Charles Todd. . . . Todd handles grave issues with great compassion”—The New York Times Book Review In a marshy Norfolk backwater, a priest is brutally murdered after giving a dying man last rites. For Scotland Yard’s Ian Rutledge, an ex-officer still recovering from the trauma of war, it looks to be a simple case. Yet the Inspector finds himself uncovering secrets that the local authorities would prefer not to see explored. Rutledge pares away layers of deception to piece together a chain of events that stretches from the brooding marshes to one of the greatest sea disasters in history—the sinking of the Titanic. Who is the mysterious woman who may have boarded that ship—and who is the secretive woman who survived it? Only Rutledge can answer those questions . . . and prevent a killer who’ll stop at nothing from striking again. Praise for Watchers of Time “One of the best historical series being written today . . . In the grand tradition of English murder mysteries.”—The Washington Post Book World “With his tortured detective Ian Rutledge and the ghost who inhabits his mind . . . Charles Todd has swiftly become one of the most respected writers in the mystery genre. . . . The pair is unique among sleuths.”—The Denver Post “Outstanding. Todd’s portrait of Rutledge and postwar England remains powerful.”—Alfred Hitchcock Mystery Magazine

The weathered remains found on a Scottish mountainside may be those of Eleanor Gray, but the imperious Lady Maude Gray, Eleanor''s mother, will have to be handled delicately. This is not the only ground that Inspector Ian Rutledge of Scotland Yard must tread carefully, for the case will soon lead him to Scotland, where many of Rutledge''s ghosts rest uneasily. But it is an unexpected encounter that will hold the most peril. For in Scotland Rutledge will find that the young mother accused of killing Eleanor Gray is a woman to whom he owes a terrible debt. And his harrowing journey to find the truth will lead him back through the fires of his past, into secrets that still have the power to kill.

Inspector Ian Rutledge is quickly sent to investigate the sudden deaths of three members of the same eminent Cornwall family, but the World War I veteran soon realizes that nothing about this case is routine. Including the identity of one of the dead, a reclusive spinster unmasked as O. A. Manning, whose war poetry helped Rutledge retain his grasp on sanity in the trenches of France. Guided by the voice of Hamish, the Scot he unwillingly executed on the battlefield, Rutledge is driven to uncover the haunting truths of murder and madness rooted in a family crypt...

CD21 is an 145Kd glycoprotien which was originally cloned from B-cells as the receptor for the complement fragment C3dg. Subsequently it was shown that CD 21 is the receptor for Epstein Barr virus (EBV) which is the causative agent of infectious mononucleosis and is associated with a variety of malignancies including B and T lineage lymphomas. The present work demonstrates CD21 expression on thymocytes and investigates the potential pathologic significance of this finding by studying the effect of EBV infection of these cells. EBV induces proliferation of phenotypically and functionally immature thymocytes in an EL-2 mediated response. An EBV superantigen was considered as a potential mechanism by which EBV may induce T-cell proliferation. To test this hypothesis, studies were performed to characterize the thymocyte response to a known superantigen, Staphyloccocal Enterotoxin B (SEB). SEB-induced proliferation of thymocytes shares some of the characteristics of EBVinduced proliferation, however, the hallmark feature of superantigens, TCR-V-beta specificity, was not identified in the EBV response. The potential biologic significance of CD21 expression on thymocytes was also investigated. No functional properties of CD21 were demonstrated. One series of experiments designed to identify CD21- associated proteins lead to the finding that CD81 is expressed at high levels onu003e99% of all thymocytes. Although CD 81 does not appear to be physically associated with CD 21 in these cells, CD 81 was investigated as an independant interest. Ligation of CDS 1 promotes LFA-1-mediated cell-cell adhesion within 1 hour of treatment. This aggregation is Ca and Mg++ dependant and requires metabolic temperature. Aggregation requires PKC activity but not PTK activity. CD 81 is physically associated with CD4 and CD8 on thymocytes as shown by coimmunoprecipitation. Finally CD 81 provides costimulation with CD3 to promote IL-2 dependant proliferation of thymocytes.

Book description to come.

Todd family letters listed below. Chiefly letters and fragments of letters written during Todd''s absence on construction of the Overland Telegraph and comprising two letters from Charles Todd to sons Charles and Hedley and to Alice Todd to River Roper and Mount Margaret 1872, sixteen letters and fragments of letters from Alice Todd to Charles Todd, mainly written from the Observatory 1872-1894, a fragment and two letters from Alice Todd to Maude 1891-ca.1897 and three letters from Elizabeth to her father Charles Todd written from the Observatory 1872. Also a letter to his family in England describing his voyage to S.A. in the ship ''Irene''. PRG 630/2/1 Charles Todd, S.S. Tararua, River Roper, to Charlie and Hedley. 20 March 1872 PRG 630/2/2 Charles Todd, Mt Margaret, to Alice Todd, 6 October 1872 PRG 630/2/3 Alice Todd, the Observatory, to Charles Todd. 23 May 1872 PRG 630/2/4 Alice Todd, the Observatory, to Charles Todd, 29 May 1872 PRG 630/2/5 Alice Todd, the Observatory, to Charles Todd, 12 June 1872 PRG 630/2/6 Alice Todd, the Observatory, to Charles Todd, 9 July 1872 PRG 630/2/7 Alice Todd, the Observatory, to Charles Todd, 24 July 1872 PRG 630/2/8 Alice Todd, the Observatory, to Charles Todd, 11 August 1872 PRG 630/2/9 Alice Todd, the Observatory, to Charles Todd, 29 August 1872 PRG 630/2/10 Alice Todd, the Observatory, to Charles Todd, 5 September 1872 PRG 630/2/11 Alice Todd, the Observatory, to Charles Todd, 9 September 1872 PRG 630/2/12 Alice Todd, the Observatory, to Charles Todd, 19 September 1872 PRG 630/2/13 Alice Todd, the Observatory, to Charles Todd, 24 September 1872 PRG 630/2/14 Alice Todd to Charles Todd. 7 October 1872 PRG 630/2/15 Alice Todd, the Observatory, to Charles Todd. 17 October 1872 PRG 630/2/16 Alice Todd to Charles Todd. 23 October 1872 PRG 630/2/17 Alice Todd, the Observatory, to (Sir) Charles Todd. 24 January 1886 PRG 630/2/18 Alice Todd, Port Elliot, to (Sir) Charles Todd. 12 March 1894 PRG 630/2/19 Alice Todd to Maude, ca.1891 PRG 630/2/20 Alice Todd, the Observatory, to Maude. 19 October 1891 PRG 630/2/21 Alice Todd to Maude. ca. December 1897 PRG 630/2/22 Lizzie Todd, the Observatory, to Charles Todd. 23 May [1872] PRG 630/2/23 Lizzie Todd, the Observatory, to Charles Todd. 29 May [1872] PRG 630/2/24 Lizzie Todd, the Observatory, to Charles Todd. 13 June [1872]