Best Selling Books by Charles Todd

Scotland Yard’s Ian Rutledge finds himself caught in a twisted web of vengeance, old grievances, and secrets that lead back to World War I in the nineteenth installment of the acclaimed bestselling series. On the eve of the bloody Battle of the Somme, a group of English officers having a last drink before returning to the Front make a promise to each other: if they survive the battle ahead—and make it through the war—they will meet in Paris a year after the fighting ends. They will celebrate their good fortune by racing motorcars they beg, borrow, or own from Paris to Nice. In November 1919, the officers all meet as planned, and though their motorcars are not designed for racing, they set out for Nice. But a serious mishap mars the reunion. In the mountains just north of their destination, two vehicles are nearly run off the road, and one man is badly injured. No one knows—or will admit to knowing—which driver was at the wheel of the rogue motorcar. Back in England one year later, during a heavy rainstorm, a driver loses control on a twisting road and is killed in the crash. Was it an accident due to the hazardous conditions? Or premeditated murder? Is the crash connected in some way to the unfortunate events in the mountains above Nice the year before? The dead driver wasn’t in France—although the motorcar he drove was. If it was foul play, was it a case of mistaken identity? Or was the dead man the intended victim after all? Investigating this perplexing case, Scotland Yard Inspector Ian Rutledge discovers that the truth is elusive—and that the villages on the South Downs, where the accident happened, are adept at keeping secrets, frustrating his search. Determined to remain in the shadows this faceless killer is willing to strike again to stop Rutledge from finding him. This time, the victim he chooses is a child, and it will take all of Rutledge’s skill to stop him before an innocent young life is sacrificed.

On a deserted road, late at night, Scotland Yard’s Ian Rutledge encounters a frightened woman standing over a body, launching an inquiry that leads him into the lair of a stealthy killer and the dangerous recesses of his own memories in this twentieth installment of the acclaimed New York Times bestselling series. Hours after his sister’s wedding, a restless Ian Rutledge drives aimlessly, haunted by the past, and narrowly misses a motorcar stopped in the middle of a desolate road. Standing beside the vehicle is a woman with blood on her hands and a dead man at her feet. She swears she didn’t kill Stephen Wentworth. A stranger stepped out in front of their motorcar, and without warning, fired a single shot before vanishing into the night. But there is no trace of him. And the shaken woman insists it all happened so quickly, she never saw the man’s face. Although he is a witness after the fact, Rutledge persuades the Yard to give him the inquiry, since he’s on the scene. But is he seeking justice—or fleeing painful memories in London? Wentworth was well-liked, yet his bitter family paint a malevolent portrait, calling him a murderer. But who did Wentworth kill? Is his death retribution? Or has his companion lied? Wolf Pit, his village, has a notorious history: in Medieval times, the last wolf in England was killed there. When a second suspicious death occurs, the evidence suggests that a dangerous predator is on the loose, and that death is closer than Rutledge knows.

In this absorbing new entry in the acclaimed New York Times bestselling series, Scotland Yard’s Ian Rutledge is caught up in a twisted web of vengeance and murder. On the north coast of Cornwall, an apparent act of mercy is repaid by an arrest for murder. Four young women have been accused of the crime. A shocked father calls in a favor at the Home Office. Scotland Yard is asked to review the case. However, Inspector Ian Rutledge is not the first Inspector to reach the village. Following in the shoes of a dead man, he is told the case is all but closed. Even as it takes an unexpected personal turn, Rutledge will require all his skill to deal with the incensed families of the accused, the grieving parents of the victim, and local police eager to see these four women sent to the infamous Bodmin Gaol. Then why hasn’t the killing stopped? With no shred of evidence to clear the accused, Rutledge must plunge deep into the darkest secrets of a wild, beautiful and dangerous place if he is to find a killer who may—or may not—hold the key to their fate.

World War I Battlefield nurse Bess Crawford’s career is in jeopardy when a murder is committed on her watch, in this absorbing and atmospheric historical mystery from New York Times bestselling author Charles Todd. Home on leave, Bess Crawford is asked to accompany a wounded soldier confined to a wheelchair to Buckingham Palace, where he’s to be decorated by the King. The next morning when Bess goes to collect Wilkins, he has vanished. Both the Army and the nursing service hold Bess negligent for losing the war hero, and there will be an inquiry. Then comes disturbing word from the Shropshire police, complicating the already difficult situation: Wilkins has been spotted, and he’s killed a man. If Bess is to save her own reputation, she must find Wilkins and uncover the truth. But the elusive soldier has disappeared again and even the Shropshire police have lost him. Suddenly, the moral implications of what has happened—that a patient in her charge has committed murder—become more important to Bess than her own future. She’s going to solve this mysterious puzzle, but righting an injustice and saving her honor may just cost Bess her life.

“You’re going to love Todd.” —Stephen King, Entertainment Weekly The critically acclaimed creator of the Inspector Ian Rutledge and battlefield nurse Bess Crawford mystery series, Charles Todd now offers readers a bittersweet love story and romantic mystery that unfolds at Christmas during the dangerous opening days of World War I. The Walnut Tree is an unforgettable story of a woman who puts herself in the line of fire for the sake of wounded soldiers and falls deeply in love with a man who may be forbidden to her. For anyone who has fallen under the spell of Downton Abbey, and for all the fans of the British-set mysteries of Elizabeth George, Anne Perry, Ruth Rendell, Martha Grimes, and Jacqueline Winspear, The Walnut Tree is essential reading.

“As always, Todd’s intense feelings for the traumatized survivors of war make one mother’s son the broken hero of an entire generation of lost souls.” — The New York Times Book Review In the aftermath of World War I, English nurse Bess Crawford attempts to save a troubled officer from a mysterious killer in this eleventh book in the acclaimed Bess Crawford mystery series. The Armistice of November 1918 ended the fighting, but the Great War will not be over until a Peace Treaty is drawn up and signed by all parties involved. Representatives from the Allies are gathering in Paris, and already ominous signs of disagreement have appeared. Sister Bess Crawford, who has been working with the severely wounded in England in the war’s wake, is asked to carry out a personal mission in Paris for a Matron at the London headquarters of The Queen Alexandra’s. Bess is facing decisions about her own future, even as she searches for Lawrence Minton. When she finally locates him, instead of the intelligent, ambitious officer she expects, she finds a bitter and disturbed man who has abdicated his duties at the Peace Conference and is well on his way toward an addiction to opiates. Indeed, he tells her that he doesn’t care if he lives or dies, he only wants oblivion. But what has changed him? What is it that haunts him? It seems the truth is buried so deep in his mind that he can only relive it in wild nightmares. When Minton goes missing, bent on suicide, Bess must race to unlock his past before he succeeds. Reluctant to trust an officer in Minton’s regiment, a man with secrets of his own, and uncertain of the loyalties of Matron’s friends in Paris, Bess must rely on her own instincts and experience—and sometimes in desperation on a stranger who claims he never met Minton. Could whatever happened to Minton in Paris somehow be connected to his war? And why did he not kill Bess when he had the chance—then later, viciously attack her without warning? What is destroying Lieutenant Minton? Or is it who? And what horror will she have to confront, if she is to save him? In this, the eleventh novel in the award-winning Bess Crawford series, New York Times bestselling author Charles Todd delivers a rich and atmospheric portrait that illuminates the cost of war on human lives—the lingering pain and horror that no peace, no matter how earned, can assuage.

World War I battlefield nurse Bess Crawford''s career and life are in jeopardy when a murder is committed on her watch. Arriving in London on leave, Bess Crawford receives an unusual summons from the War Office. She''s to accompany a wounded soldier from a northern clinic, Sergeant Jason Wilkins, to Buckingham Palace. Confined to a wheelchair, the soldier will be in her care for barely a day. But the morning after the ceremony, Wilkins is missing. Bess is blamed for losing the war hero. More disturbing news complicates her difficult situation! The Army considers Wilkins a deserter, and Scotland Yard questions her when Wilkins is suspected of killing a man. If Bess is to clear her name, she must prove that she was never his accomplice. But the sergeant has disappeared yet again. Carefully questioning unhelpful villagers, Bess and her friend, Simon, follow a trail of clues across England. But will uncovering the truth and saving her honor put more innocent people in jeopardy?

“Bess is among the most compassionate and intelligent characters.” –The Sun-Sentinel From the New York Times bestselling author of the Bess Crawford mystery series, a short story that unravels dark secrets from her close friend Simon Brandon’s past. Years before the Great War summoned Bess Crawford to serve as a battlefield nurse, the indomitable heroine spent her childhood in India under the watchful eye of her friend and confidant, the young soldier Simon Brandon. The two formed an inseparable bond on the dangerous Northwest Frontier where her father’s Regiment held the Khyber Pass against all intruders. It was Simon who taught Bess to ride and shoot, escorted her to the bazaars and the Maharani’s Palace, and did his best to keep her out of trouble, after the Crawford family took an interest in the tall, angry boy with a mysterious past. But the Crawfords have long guarded secrets for Simon and he owes them a debt that runs deeper than Bess could ever know. Told through the eyes of Melinda, Richard, Clarissa, and Bess, A Hanging at Dawn pieces together a mystery at the center of Bess’s family that will irrevocably change the course of her future.

“[Charles] Todd’s mysteries are among the most intelligent and affecting being written these days.”—The Washington Post Book World In 1912 Ian Rutledge helped gather the evidence that sent Ben Shaw to the gallows. Now, seven years later, Ben Shaw’s widow brings Rutledge evidence she’s convinced proves her husband’s innocence. Ben Shaw’s past is a tangle of unsettling secrets that may or may not be true. And it grows only more twisted when a seemingly unrelated murder brings Rutledge back to Kent. There an unexpected encounter revives his painful memories of war—and the voice of Hamish MacLeod, the soldier Rutledge was forced to execute. Two elusive killers are on the loose at the same time . . . and to catch them before they catch him, Rutledge will be forced to question everything he believes about right, wrong—and murder. Praise for A Fearsome Doubt “Brilliant . . . Who’d have thought that Charles Todd’s brilliant concept for a mystery . . . would not only continue but grow stronger from book to book.”—Chicago Tribune “Todd raises the stakes in this series to new and nearly unbearable levels.”—The New York Times Book Review “A brilliant and gripping whodunit . . . an outstanding historical mystery and literate period fiction.”—Publishers Weekly (starred review)

World War I battlefield nurse Bess Crawford goes to dangerous lengths to investigate a wounded soldier’s background—and uncover his true loyalties—in this thrilling and atmospheric entry in the bestselling “vivid period mystery series” (New York Times Book Review). At the foot of a tree shattered by shelling and gunfire, stretcher-bearers find an exhausted officer, shivering with cold and a loss of blood from several wounds. The soldier is brought to battlefield nurse Bess Crawford’s aid station, where she stabilizes him and treats his injuries before he is sent to a rear hospital. The odd thing is, the officer isn’t British—he’s French. But in a moment of anger and stress, he shouts at Bess in German. When Bess reports the incident to Matron, her superior offers a ready explanation. The soldier is from Alsace-Lorraine, a province in the west where the tenuous border between France and Germany has continually shifted through history, most recently in the Franco-Prussian War of 1870, won by the Germans. But is the wounded man Alsatian? And if he is, on which side of the war do his sympathies really lie? Of course, Matron could be right, but Bess remains uneasy—and unconvinced. If he was a French soldier, what was he doing so far from his own lines . . . and so close to where the Germans are putting up a fierce, last-ditch fight? When the French officer disappears in Paris, it’s up to Bess—a soldier’s daughter as well as a nurse—to find out why, even at the risk of her own life.

While contending with wounded soldiers and influenza patients, battlefield nurse Bess Crawford stumbles upon the body of an officer and family friend who has been murdered, and uses her father''s connections in the military to search for an elusive killer.

“If anyone can turn a simple village mystery into a brooding Greek tragedy, it’s Charles Todd. . . . Todd handles grave issues with great compassion”—The New York Times Book Review In a marshy Norfolk backwater, a priest is brutally murdered after giving a dying man last rites. For Scotland Yard’s Ian Rutledge, an ex-officer still recovering from the trauma of war, it looks to be a simple case. Yet the Inspector finds himself uncovering secrets that the local authorities would prefer not to see explored. Rutledge pares away layers of deception to piece together a chain of events that stretches from the brooding marshes to one of the greatest sea disasters in history—the sinking of the Titanic. Who is the mysterious woman who may have boarded that ship—and who is the secretive woman who survived it? Only Rutledge can answer those questions . . . and prevent a killer who’ll stop at nothing from striking again. Praise for Watchers of Time “One of the best historical series being written today . . . In the grand tradition of English murder mysteries.”—The Washington Post Book World “With his tortured detective Ian Rutledge and the ghost who inhabits his mind . . . Charles Todd has swiftly become one of the most respected writers in the mystery genre. . . . The pair is unique among sleuths.”—The Denver Post “Outstanding. Todd’s portrait of Rutledge and postwar England remains powerful.”—Alfred Hitchcock Mystery Magazine

“One of the best historical series being written today.” —Washington Post “Todd once and for all establishes the shell-shocked Rutledge as the genre’s most complex and fascinating detective.” —Entertainment Weekly The Confession is historical crime fiction at its finest, continuing Charles Todd’s New York Times bestselling mystery series featuring severely damaged British World War I veteran, and yet still astonishingly efficient Scotland Yard inspector, Ian Rutledge. Todd’s troubled investigator wrestles with a startling and dangerous case that reaches far into the past when a false confession from a man who is not who he claims to be leads to a brutal murder. The Confession is a must-read for every fan of Elizabeth George, Martha Grimes, P.D. James, Ruth Rendell, and Jacqueline Winspear, as post-war London’s best detective finds himself ensnared in a dark and deadly investigation that unearths shocking small town secrets dating back more than a century.

Rutledge must investigate the puzzling murders of at least one man, and the cases seem to be connected with World War I.

World War I nurse Bess Crawford, introduced in A Duty to the Dead, returns in an exciting new mystery in which a murder draws her inexorably into the sights of a cunning killer It is the early summer of 1917. Bess Crawford has returned to England from the trenches of France with a convoy of severely wounded men. One of her patients is a young pilot who has been burned beyond recognition, and who clings to life and the photo of his wife that is pinned to his tunic. While passing through a London train station, Bess notices a woman bidding an emotional farewell to an officer, her grief heart-wrenching. And then Bess realizes that she seems familiar. In fact, she''s the woman in the pilot''s photo, but the man she is seeing off is not her husband. Back on duty in France, Bess discovers a newspaper with a drawing of the woman''s face on the front page. Accompanying the drawing is a plea from Scotland Yard seeking information from anyone who has seen her. For it appears that the woman was murdered on the very day Bess encountered her at the station. Granted leave to speak with Scotland Yard, Bess becomes entangled in the case. Though an arrest is made, she must delve into the depths of her very soul to decide if the police will hang an innocent man or a vicious killer. Exposing the truth is dangerous—and will put her own life on the line.

Trying to help a woman in distress, World War I nurse and accidental sleuth Bess Crawford learns that no good deed goes unpunished When battlefield nurse Bess Crawford returns from France for a well-earned Christmas leave, she finds a bruised and shivering woman huddled in the doorway of her London residence. The woman has nowhere to turn, and propelled by a firm sense of duty, Bess takes her in. Once inside Bess’s flat, the woman reveals that a quarrel with her husband erupted into violence, yet she wants to return home—if Bess will go with her to Sussex. Realizing that the woman is suffering from a concussion, Bess gives up a few precious days of leave to travel with her. But she soon discovers that this is a good deed with unforeseeable consequences. What Bess finds at Vixen Hill is a house of mourning. The woman’s family has gathered for a memorial service for the elder son, who died of war wounds. Her husband, home on compassionate leave, is tense, tormented by jealousy and his own guilty conscience. Then, when a troubled houseguest is found dead, Bess herself becomes a prime suspect in the case. This murder will lead her to a dangerous quest in war-torn France, an unexpected ally, and a startling revelation that puts her in jeopardy before a vicious killer can be exposed.

“Full of suspense, surprises, and sympathetic characters.” —Fort Lauderdale Sun-Sentinel “No mystery series I can think of captures the sadness and loss that swept over England after World War I with the heartbreaking force of Charles Todd’s books about Scotland Yard Inspector Ian Rutledge.” —Chicago Tribune The remarkable Charles Todd has created one of the most unforgettable characters in mystery and crime fiction: Inspector Ian Rutledge, shell-shocked veteran of “the Great War.” A False Mirror is one of Todd’s most powerful novels, plunging his tormented protagonist into the center of a brutal crime that painfully echoes events in Rutledge’s own past. Poignant, evocative, and continually surprising, A False Mirror is further proof that Charles Todd is well deserving of the critical acclaim the Rutledge novels have earned; a New York Times bestselling author who belongs among the acknowledged masters of the genre, including P. D. James, Elizabeth George, Ruth Rendell, and Jacqueline Winspear.

Scotland Yard inspector Ian Rutledge returns shell shocked from the trenches of World War I, tormented by the memory of Hamish MacLeod, the young Scots soldier he executed on the battlefield. Now, Charles Todd features Hamish himself in this compelling, stand-alone short story. Before the Great War, Hamish farms in the Highlands, living in a small croft on the hillside and caring for a flock of sheep he inherited from his grandmother. When at the height of a spring gale, he hears a faint cry echoing across the glen, Hamish sets out into the stormy night to find the source. Near the edge of the loch he spots a young boy lying wounded, a piper’s bag beside him. Hamish brings the piper to his home to stay the night and tends to his head wound, but by the time Hamish wakes the boy has vanished. Worried, he goes in pursuit of the injured piper and finds him again collapsed in the heather--dead. Who was the mysterious piper, and who was seeking his death? As Hamish scours the countryside for answers, he finds that few of his neighbors are as honest as he, and that until he uncovers a motive, everyone, including Hamish, is a suspect.

A horrific explosion at a gunpowder mill sends Bess Crawford to war-torn France to keep a deadly pattern of lies from leading to more deaths, in this compelling and atmospheric mystery from the New York Times bestselling author of A Question of Honor and An Unwilling Accomplice. An explosion and fire at the Ashton Gunpowder Mill in Kent has killed over a hundred men. It’s called an appalling tragedy—until suspicion and rumor raise the specter of murder. While visiting the Ashton family, Bess Crawford finds herself caught up in a venomous show of hostility that doesn’t stop with Philip Ashton’s arrest. Indeed, someone is out for blood, and the household is all but under siege. The only known witness to the tragedy is now at the Front in France. Bess is asked to find him. When she does, he refuses to tell her anything that will help the Ashtons. Realizing that he believes the tissue of lies that has nearly destroyed a family, Bess must convince him to tell her what really happened that terrible Sunday morning. But now someone else is also searching for this man. To end the vicious persecution of the Ashtons, Bess must risk her own life to protect her reluctant witness from a clever killer intent on preventing either of them from ever reaching England.

“Todd’s Ian Rutledge mysteries are among the most intelligent and affecting being written these days.” —Washington Post Critics have called Charles Todd’s historical mystery series featuring shell-shocked World War One veteran Inspector Ian Rutledge “remarkable” (New York Times Book Review), “heart-breaking” (Chicago Tribune), “fresh and original” (South Florida Sun-Sentinel). In A Lonely Death, the haunted investigator is back in action, trying to solve the murders of three ex-soldiers in a small English village. A true master of evocative and atmospheric British crime fiction, Charles Todd reaches breathtaking new heights with A Lonely Death—a thrilling tale of the darkness in men’s souls that will have fans of Elizabeth George, Martha Grimes, and Anne Perry cheering.

Living with her family in India, young Bess Crawford''s curiosity about this exotic country sometimes leads her into trouble. One day she slips away from the cantonment to visit the famous seer in a nearby village. Before this woman can finish telling her fortune, Bess is summoned back for an afternoon tea with the Maharani, a close friend of her parents''. The seer''s last words are a warning about forthcoming danger that Bess takes as the usual patter. But this visit by the Maharani has ominous overtones that mark it as more than a social call. Her husband has political enemies, and she has come to ask Bess''s father, Major Crawford, for help. As the Maharani is leaving, Bess notices that there is something amiss with the royal entourage. Major Crawford must set out after them—but will he be in time? And what will happen to Bess, and the household left behind, when a vicious assassin circles back to take hostages? Here is an extraordinary glimpse into the childhood of the Bess Crawford we know from her service in the Great War.

Five novellas about deadly books—and even more dangerous people—from five acclaimed mystery authors. Book Club: Ex-cop Avery Sharecross now spends his days tracking rare books in Good Advice, New Mexico. But his old career collides with his new one when the local sheriff asks him for help on a case of a dead book collector. Seven Years: New York Times–bestselling author Peter Robinson tells of a retired professor who discovers a threatening inscription in a volume of Robert Browning’s poetry. Puzzled by the disturbing message, he can’t resist playing detective. But the professor is about to learn the consequences of reading between the lines. The Final Testament: In this historical tale from New York Times–bestselling author Peter Blauner, a Nazi in 1938 London attempts to blackmail Sigmund Freud into publishing an anti-Semitic book in Freud’s name. Freud retaliates by picking up pen and paper and suggesting his blackmailer sit on his couch. The Pretty Little Box: New York Times–bestselling author Charles Todd presents a story of an Englishwoman’s simple theft of a devotional that sets in motion a dreadful chain of events. Pronghorns of the Third Reich: New York Times–bestselling author C. J. Box brings us to frigid Wyoming, where Lyle and Juan wait outside a lawyer’s house in ski masks and carrying pistols. Lyle is convinced he’s owed something, but he’s about to uncover a mystery that stretches back to Nazi Germany.

This is a special issue—our 50th, as you may have noticed from our cover. To celebrate, all past and present editors were to contribute a story. (It helps that they are also amazingly talented writers.) So we have stories from Michael Bracken, Barb Goffman, Paul Di Filippo, Darrell Schweitzer, and Cynthia Ward in addition to our other fare. But wait! There’s more! This issue features four original tales—Elizabeth Zelvin has a fantasy/mystery stories, Phyllis Ann Karr has a weird western, and Cynthia Ward has a gonzo science fiction crowd-funding story. And I have completed a story by the late H.B. Fyfe, who was best known for his science fiction stories, though this one is a revenge tale that most closely fits the mystery genre. And the good stuff doesn’t stop there. We also have a superhero story from Darrell Schweitzer. Space Opera from Algis Budrys and E.E. “Doc” Smith. A historical mystery novel by western author B.M. Bower. A historical investigation from Charles Todd. A Mallworld story from Somtow Sucharitkul (who also writes as S.P. Somtow). And no issue is complete without a solve-it-yourself mystery by Hal Charles. All in all, this is an probably our best Black Cat Weekly yet. Here’s the complete lineup: Mysteries / Suspense / Adventure: “The Ladies of Wednesday Tea” by Michael Bracken [short story] “Hidden in Plain Sight” by Hal Charles [Solve-It-Yourself Mystery] “Ice Ice Baby” by Barb Goffman [short story] “Flayed” by H.B. Fyfe and John Gregory Betancourt [short story] “Blood Money” by Charles Todd [Barb Goffman Presents short story] “The House of Marble” by Elizabeth Zelvin [Michael Bracken Presents short story] The Eagle’s Wing, by B.M. Bower [novel] Science Fiction & Fantasy: “The House of Marble” by Elizabeth Zelvin [Michael Bracken Presents short story] “The Rise and Fall of Whistle-Pig City” by Paul Di Filippo [short story] “Rabid in Mallworld” by Somtow Sucharitkul [short story] “Fighting the Zeppelin Gang” by Darrell Schweitzer [short story] “Winona of Bleeding Kansas” by Phyllis Ann Karr [short story] “The Campaign Is Now Officially Complete” by Cynthia Ward [short story] “Blood on my Jets” by Algis Budrys [short story] The Skylark of Valeron, by Edward E. Smith, Ph.D. [novel]

CD21 is an 145Kd glycoprotien which was originally cloned from B-cells as the receptor for the complement fragment C3dg. Subsequently it was shown that CD 21 is the receptor for Epstein Barr virus (EBV) which is the causative agent of infectious mononucleosis and is associated with a variety of malignancies including B and T lineage lymphomas. The present work demonstrates CD21 expression on thymocytes and investigates the potential pathologic significance of this finding by studying the effect of EBV infection of these cells. EBV induces proliferation of phenotypically and functionally immature thymocytes in an EL-2 mediated response. An EBV superantigen was considered as a potential mechanism by which EBV may induce T-cell proliferation. To test this hypothesis, studies were performed to characterize the thymocyte response to a known superantigen, Staphyloccocal Enterotoxin B (SEB). SEB-induced proliferation of thymocytes shares some of the characteristics of EBVinduced proliferation, however, the hallmark feature of superantigens, TCR-V-beta specificity, was not identified in the EBV response. The potential biologic significance of CD21 expression on thymocytes was also investigated. No functional properties of CD21 were demonstrated. One series of experiments designed to identify CD21- associated proteins lead to the finding that CD81 is expressed at high levels onu003e99% of all thymocytes. Although CD 81 does not appear to be physically associated with CD 21 in these cells, CD 81 was investigated as an independant interest. Ligation of CDS 1 promotes LFA-1-mediated cell-cell adhesion within 1 hour of treatment. This aggregation is Ca and Mg++ dependant and requires metabolic temperature. Aggregation requires PKC activity but not PTK activity. CD 81 is physically associated with CD4 and CD8 on thymocytes as shown by coimmunoprecipitation. Finally CD 81 provides costimulation with CD3 to promote IL-2 dependant proliferation of thymocytes.