Best Selling Books by Brian Curtis

Construction Coloring Book For Kids!Whether Steam Rollers, Dump Trucks, Excavators, Cranes, Cement Trucks, and More Construction color book for kids is sure to satisfy your little building enthusiast! Coloring book for kids who love trucks will be thrilled with this fun-packed Construction Coloring Book! This coloring book for kids will provide hours of fun for boys and girls. This Construction Coloring Book Features: Large 8 1/2 x 11 inch pages 30 unique images Big variety of construction vehicles High-resolution printing 30 Unique designs, no repeats Single-sided pages for no bleed through Printed on bright white, 60 lb stock Durable cover High-quality book Made in USA Makes a great construction-themed gift for kids! Buy Now, Start Coloring... Scroll to the top of the page and click the buy button.

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The aim of this work was to obtain a fundamental understanding of drug release mechanisms from polymers that undergo thermoreversible gelation and to synthesize new polymers based on these that exhibit both pH and temperature sensitivity. Novel block and random copolymers with cationic character have been developed for drug delivery and gene therapy applications. The development of these materials began with a study of the mechanism of drug release from poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) block copolymers. This study revealed the release rates of drugs from water-soluble hydrogels composed of the PEO-PPO-PEO block copolymer Pluronic F127 was dictated almost solely by the rate of interfacial dissolution at the water/gel interface. A setup was designed to measure drug release from such soluble systems in order to avoid confounding hydrodynamic effects as a result of shear on the delicate polymer/gel interface. This study was followed by a complementary analysis of the effect ionic salts play in the phase transitions and drug release profiles in aqueous F127 solutions. In an attempt to incorporate pH sensitivity into such drug release systems, several block copolymers of poly (N, N-diethylaminoethyl methacrylate) (PDEAEM), PEO, and PPO were synthesized via anionic polymerization. Diblock materials (PEO-b-PDEAEM), either with or without a carboxylic acid endcap, were synthesized and characterized. Tablet dissolution experiments demonstrated pH-sensitivity in their drug release profiles relative to PEO tablets. Pentablock materials (PDEAEM-b-PEO-b-PPO-b-PEO-b-PDEAEM) were synthesized that maintain the thermoreversible gelation and micellization properties of F127 while introducing pH-dependent release from aqueous gels of the copolymer. This is the first example of non-crosslinked materials that exhibit both pH- and temperature-sensitive behavior. Using a similar synthesis route, random copolymers of PDEAEM and poly(poly(ethylene glycol) methyl ether methacrylate)) (PEGME) were synthesized which are water soluble and non-crytotoxic, whereas homopolymers of PDEAEM are neither. These materials have potential as gene therapy vectors.

(cont.) This thesis presents a detailed, atomistic-level computer simulation and molecular-thermodynamic investigation of the micellar solution behavior of nonionic, zwitterionic, and ionic surfactants in aqueous solutions, as well as of the aqueous micellar solubilization of solubilizates by surfactants. It is hoped that the approaches developed in this thesis to use computer simulations and molecular-thermodynamic theory in a complementary way will not only extend our ability to make accurate predictions of surfactant solution behavior, but will also contribute to our fundamental knowledge of the solution behavior of surfactants and solubilizates. It is further hoped that this thesis will provide a solid foundation for future research in the area of surfactant science, and, more generally, that it will assist future researchers working to connect atomistic-level computer simulation methods with continuum thermodynamic models.

ORCLE (Optical/RF Combined Link Experiment), is an airborne network in which aircraft have multiple directional antennas that are restricted in their pointing direction. A pair of aircraft in ORCLE can be linked if they both have an antenna pointing at each other. Four topology algorithms, which coordinate the pointing of the antennas and attempt to maximize a connectedness metric, are presented and analyzed using a custom 2D simulation platform. Three of the algorithms are based on the Relative Neighbor Graph (RNG): the first constrains the RNG to requirements of the ORCLE network, the second augments the constrained RNG with edges from the Delaunay Triangulation, and the third algorithm tries to improve on the second by adding edges to reduce the diameter. The final algorithm uses a novel concept of overlapping sets of nested convex hulls to select the links of the network. All algorithms are stateless and interface with a Target Transition Layer, which gradually migrates topologies to prevent a large number of edges from being lost simultaneously. Scenes with varying node density, number of terminals per node, fields of view, and re-targeting delays are used to test the algorithms against a wide range of possible situations.